TY - JOUR
T1 - New insights into the regulation of erythroid cells
AU - Ingley, Evan
AU - Tilbrook, P.A.
AU - Klinken, S.P.
PY - 2004
Y1 - 2004
N2 - The regulation of erythroid cells is complex and occurs at multiple levels. Erythroid precursors, once committed to this lineage, develop in association with specific macrophages within erythroblastic islands. While erythropoietin (Epo) is the principal regulator of erythroid progenitors, other cytokines and nuclear hormones also play an important role in the maturation of these cells. Signalling from the Epo-receptor activates several pathways, including the JAK/STAT, ras/raf/MAP kinase and PI3 kinase/Akt cascades to promote cell survival, proliferation and differentiation. Transcription factors such as GATA-1, EKLF and NF-E2 are crucial for progression along the erythroid maturation pathway; these, and a myriad of other transcription factors, must be expressed at the correct developmental stage for normal red blood cells to be formed.
AB - The regulation of erythroid cells is complex and occurs at multiple levels. Erythroid precursors, once committed to this lineage, develop in association with specific macrophages within erythroblastic islands. While erythropoietin (Epo) is the principal regulator of erythroid progenitors, other cytokines and nuclear hormones also play an important role in the maturation of these cells. Signalling from the Epo-receptor activates several pathways, including the JAK/STAT, ras/raf/MAP kinase and PI3 kinase/Akt cascades to promote cell survival, proliferation and differentiation. Transcription factors such as GATA-1, EKLF and NF-E2 are crucial for progression along the erythroid maturation pathway; these, and a myriad of other transcription factors, must be expressed at the correct developmental stage for normal red blood cells to be formed.
U2 - 10.1080/15216540410001703956
DO - 10.1080/15216540410001703956
M3 - Article
C2 - 15230344
VL - 56
SP - 177
EP - 184
JO - International Union of Biochemistry and Molecular Biology, Inc.- IUBMB Life
JF - International Union of Biochemistry and Molecular Biology, Inc.- IUBMB Life
SN - 1521-6543
IS - 4
ER -