Neuroinflammation, Type 2 diabetes, and dementia

Connie H.Y. Wong, Brooke J. Wanrooy, David G. Bruce

Research output: Chapter in Book/Conference paperChapter

2 Citations (Scopus)

Abstract

Neuroinflammation is a strong candidate to explain, at least in part, the increased dementia risk in type 2 diabetes (T2D). Currently, this hypothesis is largely circumstantial, based on clinical and experimental findings indicating that neuroinflammation has a more important role in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD) than previously considered and evidence that T2D is a disorder with a strong inflammatory component that may promote neuroinflammation. A number of animal models have been studied that indicate that T2D or related pathophysiological processes are able to exacerbate AD-related processes via inflammatory pathways. Advances in positron emission tomography with radioligands that quantify neuroinflammation provide an opportunity to study whether chronic peripheral inflammatory states seen in T2D lead to increased neuroinflammation and contribute to cognitive decline in this common age-related condition.

Original languageEnglish
Title of host publicationType 2 Diabetes and Dementia
EditorsVelandai Srikanth, Zoe Arvanitakis
Place of PublicationNetherlands
PublisherElsevier
Chapter10
Pages195-209
Number of pages15
Edition1st
ISBN (Electronic)9780128096949
ISBN (Print)9780128094549
DOIs
Publication statusPublished - 6 Mar 2018

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  • Cite this

    Wong, C. H. Y., Wanrooy, B. J., & Bruce, D. G. (2018). Neuroinflammation, Type 2 diabetes, and dementia. In V. Srikanth, & Z. Arvanitakis (Eds.), Type 2 Diabetes and Dementia (1st ed., pp. 195-209). Elsevier. https://doi.org/10.1016/B978-0-12-809454-9.00010-X