Neuroimaging manifestations of paediatric histiocytoses

Hsern Ern Tan, Rahul Lakshmanan, Dr Richard R. Warne, Tom Walwyn, Derek Roebuck

Research output: Contribution to journalReview articlepeer-review


Histiocytoses are rare multi-system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations. Classified into five groups in 2016, including Langerhans-related (L), cutaneous (C), malignant (M), Rosai–Dorfman disease (R) and haemophagocytic lymphohistiocytosis (H), newer entities such as ALK-positive histiocytosis have also emerged, heralding the era of molecular (sub)classification. Common entities include Langerhans cell histiocytosis (LCH), Erdheim–Chester disease (ECD), Rosai–Dorfman disease (RDD) and haemophagocytic lymphohistiocytosis (HLH). This pictorial essay aids radiologists in recognising and differentiating paediatric histiocytoses based on unique neuroimaging features. © 2023 The Royal Australian and New Zealand College of Radiologists.
Original languageEnglish
Number of pages15
JournalJournal of Medical Imaging and Radiation Oncology
Publication statusE-pub ahead of print - Nov 2023

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