This thesis will explore topographic organisation in the context of field theory. In the first instance it will be shown that spiketiming-dependent plasticity in conjunction with spatio-temporally correlated activity can support topographic organisation (or re-organisation). This result is important because it is known that the activity that drives organisation in development is in the form of spatio-temporally correlated waves. The model is computationally analysed .and shown to support planar/radial wave refinement, noise tolerance, direction selectivity, and refinement of ectopic projections. These results inform interpretation of current data showing topographic error correction of ephrinA2A5 mice using magnetic stimulation.
|Qualification||Doctor of Philosophy|
|Award date||13 Nov 2018|
|Publication status||Unpublished - 2018|