Neonatal tolerance under breastfeeding influence

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Diseases due to defect in tolerance induction such as allergy, celiac disease, or Type 1 Diabetes develop mostly in childhood indicating the necessity of early intervention for primary prevention. Epidemiological studies report that breastfeeding could protect from these diseases. However, data are controversial and the mechanisms unclear. Experimental data suggest that breastfeeding-induced protection might rely on tolerance induction as long as some criteria are fulfilled. Thus, the tolerogenic potential of breast milk would depend on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast milk-mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast milk and of its impact on neonatal gut and immune system maturation. The better understanding of maternal influence on tolerance induction through breastfeeding should allow the development of new strategies to prevent immune-mediated diseases.

Original languageEnglish
Pages (from-to)623-630
Number of pages8
JournalCurrent Opinion in Immunology
Volume22
Issue number5
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

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Human Milk
Breast Feeding
Antigens
Maternal Exposure
Immune System Diseases
Celiac Disease
Primary Prevention
Type 1 Diabetes Mellitus
Epidemiologic Studies
Immune System
Hypersensitivity
Breast
Epithelium
Mothers

Cite this

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title = "Neonatal tolerance under breastfeeding influence",
abstract = "Diseases due to defect in tolerance induction such as allergy, celiac disease, or Type 1 Diabetes develop mostly in childhood indicating the necessity of early intervention for primary prevention. Epidemiological studies report that breastfeeding could protect from these diseases. However, data are controversial and the mechanisms unclear. Experimental data suggest that breastfeeding-induced protection might rely on tolerance induction as long as some criteria are fulfilled. Thus, the tolerogenic potential of breast milk would depend on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast milk-mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast milk and of its impact on neonatal gut and immune system maturation. The better understanding of maternal influence on tolerance induction through breastfeeding should allow the development of new strategies to prevent immune-mediated diseases.",
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Neonatal tolerance under breastfeeding influence. / Verhasselt, Valérie.

In: Current Opinion in Immunology, Vol. 22, No. 5, 10.2010, p. 623-630.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Neonatal tolerance under breastfeeding influence

AU - Verhasselt, Valérie

PY - 2010/10

Y1 - 2010/10

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AB - Diseases due to defect in tolerance induction such as allergy, celiac disease, or Type 1 Diabetes develop mostly in childhood indicating the necessity of early intervention for primary prevention. Epidemiological studies report that breastfeeding could protect from these diseases. However, data are controversial and the mechanisms unclear. Experimental data suggest that breastfeeding-induced protection might rely on tolerance induction as long as some criteria are fulfilled. Thus, the tolerogenic potential of breast milk would depend on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast milk-mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast milk and of its impact on neonatal gut and immune system maturation. The better understanding of maternal influence on tolerance induction through breastfeeding should allow the development of new strategies to prevent immune-mediated diseases.

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