TY - JOUR
T1 - Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea
AU - Van Den Biggelaar, Anita
AU - Richmond, Peter
AU - Pomat, W.S.
AU - Phuanukoonnon, S.
AU - Nadal-Sims, M.A.
AU - Devitt, C.J.
AU - Siba, P.M.
AU - Lehmann, Deborah
AU - Holt, Patrick
PY - 2009
Y1 - 2009
N2 - The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM197 compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses.
AB - The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM197 compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses.
U2 - 10.1016/j.vaccine.2008.12.046
DO - 10.1016/j.vaccine.2008.12.046
M3 - Article
C2 - 19150378
SN - 0264-410X
VL - 27
SP - 1340
EP - 1347
JO - Vaccine
JF - Vaccine
IS - 9
ER -
