Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea

Anita Van Den Biggelaar, Peter Richmond, W.S. Pomat, S. Phuanukoonnon, M.A. Nadal-Sims, C.J. Devitt, P.M. Siba, Deborah Lehmann, Patrick Holt

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM197 compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses.
Original languageEnglish
Pages (from-to)1340-1347
JournalVaccine
Volume27
Issue number9
DOIs
Publication statusPublished - 2009

Fingerprint Dive into the research topics of 'Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea'. Together they form a unique fingerprint.

Cite this