Neonatal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches

Andrew Gill, G. Madsen, M. Knox, A. Bisits, W. Giles, D. Tudehope, Y. Rogers, R. Smith

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Objective: The object of this study was to determine the effects of maternal tocolysis with glycerol trinitrate (GTN) patches on the neurodevelopment of infants.Study design: This was a randomized, multicenter, controlled trial comparing the efficacy of GTN patches with standard beta 2 agonist as tocolytic therapy. The previously reported outcomes of this study indicated no difference in neonatal mortality or morbidity to hospital discharge. One hundred fifty-six surviving infants from 2 Australian centers were psychometrically assessed using the Griffiths Mental development Scales (revised) at 18 months of age.Results: There was no difference in psychometric performance between those infants enrolled in either the GTN (81 infants) or beta 2 agonist (75 infants) arm of the study.Conclusion: This randomized trial supports no significant difference between GTN patches in comparison with standard beta 2 agonist for tocolytic therapy. The results underscore the association between premature labor and adverse infant outcomes. (c) 2006 Mosby, Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)484-487
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume195
    DOIs
    Publication statusPublished - 2006

    Fingerprint

    Dive into the research topics of 'Neonatal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches'. Together they form a unique fingerprint.

    Cite this