Neonatal congenital microvillus atrophy

N. Pecache; Sanjay Patole; Ronald Hagan; D. Hill; Adrian Charles; John Papadimitriou

doi:10.1136/pmj.2003.007930

Neonatal congenital microvillus atrophy

N. Pecache, Sanjay Patole, Ronald Hagan, D. Hill, Adrian Charles, John Papadimitriou

Graduate Research School

Research output: Contribution to journal › Review article

17 Citations (Scopus)

Abstract

Congenital microvillous atrophy (CMVA) is the leading cause of neonatal secretory diarrhoea with onset either in the first 72 hours of life ( early onset) or at 6 - 8 weeks after birth ( late onset). To date over 30 cases have been reported worldwide. The prognosis for this life threatening condition continues to be poor. Therapeutic agents like somatostatin and epidermal growth factor are either ineffective or of marginal benefit. Overall five year survival after small bowel transplantation is currently similar to50%. The following brief review is aimed towards helping neonatologists/ perinatologists in the early diagnosis, and management of CMVA and in counselling the parents appropriately.

Original language	English
Pages (from-to)	80-83
Journal	Postgraduate Medical Journal
Volume	80
Issue number	940
DOIs	https://doi.org/10.1136/pmj.2003.007930
Publication status	Published - 2004

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@article{33a3536a5a3041dabb053d870dfce2db,

title = "Neonatal congenital microvillus atrophy",

abstract = "Congenital microvillous atrophy (CMVA) is the leading cause of neonatal secretory diarrhoea with onset either in the first 72 hours of life ( early onset) or at 6 - 8 weeks after birth ( late onset). To date over 30 cases have been reported worldwide. The prognosis for this life threatening condition continues to be poor. Therapeutic agents like somatostatin and epidermal growth factor are either ineffective or of marginal benefit. Overall five year survival after small bowel transplantation is currently similar to50%. The following brief review is aimed towards helping neonatologists/ perinatologists in the early diagnosis, and management of CMVA and in counselling the parents appropriately.",

author = "N. Pecache and Sanjay Patole and Ronald Hagan and D. Hill and Adrian Charles and John Papadimitriou",

year = "2004",

doi = "10.1136/pmj.2003.007930",

language = "English",

volume = "80",

pages = "80--83",

journal = "Postgraduate Medical Journal",

issn = "0032-5473",

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TY - JOUR

T1 - Neonatal congenital microvillus atrophy

AU - Pecache, N.

AU - Patole, Sanjay

AU - Hagan, Ronald

AU - Hill, D.

AU - Charles, Adrian

AU - Papadimitriou, John

PY - 2004

Y1 - 2004

N2 - Congenital microvillous atrophy (CMVA) is the leading cause of neonatal secretory diarrhoea with onset either in the first 72 hours of life ( early onset) or at 6 - 8 weeks after birth ( late onset). To date over 30 cases have been reported worldwide. The prognosis for this life threatening condition continues to be poor. Therapeutic agents like somatostatin and epidermal growth factor are either ineffective or of marginal benefit. Overall five year survival after small bowel transplantation is currently similar to50%. The following brief review is aimed towards helping neonatologists/ perinatologists in the early diagnosis, and management of CMVA and in counselling the parents appropriately.

AB - Congenital microvillous atrophy (CMVA) is the leading cause of neonatal secretory diarrhoea with onset either in the first 72 hours of life ( early onset) or at 6 - 8 weeks after birth ( late onset). To date over 30 cases have been reported worldwide. The prognosis for this life threatening condition continues to be poor. Therapeutic agents like somatostatin and epidermal growth factor are either ineffective or of marginal benefit. Overall five year survival after small bowel transplantation is currently similar to50%. The following brief review is aimed towards helping neonatologists/ perinatologists in the early diagnosis, and management of CMVA and in counselling the parents appropriately.

U2 - 10.1136/pmj.2003.007930

DO - 10.1136/pmj.2003.007930

M3 - Review article

SN - 0032-5473

VL - 80

SP - 80

EP - 83

JO - Postgraduate Medical Journal

JF - Postgraduate Medical Journal

IS - 940

ER -

Neonatal congenital microvillus atrophy

Abstract

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