Projects per year
Abstract
Non-small cell lung cancer (NSCLC) causes 19% of all Australian cancer deaths, with a 5-year survival post-resection of around 60%. Post-operative recurrence is due to metastases that were undetectable pre-operatively, or growth of microscopic locoregional residual disease. However, post-operative imaging modalities typically only detect more advanced tumours; where PET-CT has a detection limit of 6-7 mm. Detection of small deposits of lung metastatic disease is of importance in order to facilitate early and potentially more effective treatment. In this study, in a murine model of lung metastatic disease, we explore whether neo-antigen specific T cells are a sensitive marker for the detection of lung cancer after primary tumour resection. We determine lung metastatic disease by histology, and then compare detection by PET-CT and neo-antigen specific T cell frequency. Detection of lung metastatic disease within the histology positive group by PET-CT and neo-antigen specific T cell frequency were 22.9% and 92.2%, respectively. Notably, neo-antigen specific T cells in the lung draining lymph node were indicative of metastatic disease (82.8 ± 12.9 spots/105 cells; mean ± SE), compared to healthy lung control (28.5 ± 8.6 spots/105 cells; mean ± SE). Potentially, monitoring tumour neo-antigen specific T cell profiles is a highly sensitive method for determining disease recurrence.
Original language | English |
---|---|
Article number | 14640 |
Number of pages | 1 |
Journal | Scientific Reports |
Volume | 9 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Dec 2019 |
Fingerprint
Dive into the research topics of 'Neo-antigen specific T cell responses indicate the presence of metastases before imaging'. Together they form a unique fingerprint.Projects
- 4 Finished
-
The relationship between cancer surgery, lymph nodes, T cells and immunotherapy
Robinson, B. (Investigator 01), Saunders, C. (Investigator 02), Brown, M. (Investigator 03), Fear, V. (Investigator 04), Waithman, J. (Investigator 05) & Chee, J. (Investigator 06)
NHMRC National Health and Medical Research Council
1/01/18 → 31/12/20
Project: Research
-
National Centre for Asbestos Related Diseases
Robinson, B. (Investigator 01), Creaney, J. (Investigator 02), Lake, R. (Investigator 03), Nowak, A. (Investigator 04), Musk, A. (Investigator 05), Lesterhuis, W. (Investigator 06) & Lee, G. (Investigator 07)
NHMRC National Health and Medical Research Council
1/01/16 → 31/12/20
Project: Research
-
Reactivities of CD8 T cells to mutated neo-antigens in lung malignancies
Robinson, B. (Investigator 01), Creaney, J. (Investigator 02), Lake, R. (Investigator 03), Lesterhuis, W. (Investigator 04) & Watson, M. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/16 → 31/12/19
Project: Research