Neisseria meningitidis porA, fetA and fHbp gene distribution in Western Australia 2000 to 2011

P. Boan; N. Metasan; S.S. Tempone; G.B. Harnett; David Speers; A.D. Keil

doi:10.1186/s12879-014-0686-x

Neisseria meningitidis porA, fetA and fHbp gene distribution in Western Australia 2000 to 2011

P. Boan, N. Metasan, S.S. Tempone, G.B. Harnett, David Speers, A.D. Keil

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Abstract

© Boan et al. Background: PorA, fetA and fHbp are three antigen encoding genes useful for meningococcal typing and FHbp is an important component of meningococcal B vaccines. Methods: We performed sequence analysis of meningococcal , and genes on 128 isolates from Western Australia, relating results to age, gender, race and geographic region. Results: We found predominantly PorA subtypes P1.22,14-16 (n=23) and P1.7-2,4 (n=19); FetA subtypes F1-5 (n=41), F3-6 (n=11), F5-1 (n=10), F5-2 (n=9), F5-5 (n=8), F3-3 (n=8); and FHbp variant groups 1 (n=65) and 2 (n=44). PorA P1.22,14-16 and FHbp variant group 2 were associated with younger age and aboriginality. Conclusions: FHbp modular groups of the bivalent recombinant FHbp vaccine and the multicomponent 4CMenB vaccine make up 8.3% and 47.7% respectively of the examined serogroup B isolates from 2000-2011, however to estimate vaccine efficacy requires an account of all vaccine antigens and their levels of expression.

Original language	English
Pages (from-to)	1-7
Journal	BMC Infectious Diseases
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s12879-014-0686-x
Publication status	Published - 2014

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@article{c8078b8291c541d98f731e6e608aaf4e,

title = "Neisseria meningitidis porA, fetA and fHbp gene distribution in Western Australia 2000 to 2011",

abstract = "{\textcopyright} Boan et al. Background: PorA, fetA and fHbp are three antigen encoding genes useful for meningococcal typing and FHbp is an important component of meningococcal B vaccines. Methods: We performed sequence analysis of meningococcal , and genes on 128 isolates from Western Australia, relating results to age, gender, race and geographic region. Results: We found predominantly PorA subtypes P1.22,14-16 (n=23) and P1.7-2,4 (n=19); FetA subtypes F1-5 (n=41), F3-6 (n=11), F5-1 (n=10), F5-2 (n=9), F5-5 (n=8), F3-3 (n=8); and FHbp variant groups 1 (n=65) and 2 (n=44). PorA P1.22,14-16 and FHbp variant group 2 were associated with younger age and aboriginality. Conclusions: FHbp modular groups of the bivalent recombinant FHbp vaccine and the multicomponent 4CMenB vaccine make up 8.3% and 47.7% respectively of the examined serogroup B isolates from 2000-2011, however to estimate vaccine efficacy requires an account of all vaccine antigens and their levels of expression.",

author = "P. Boan and N. Metasan and S.S. Tempone and G.B. Harnett and David Speers and A.D. Keil",

year = "2014",

doi = "10.1186/s12879-014-0686-x",

language = "English",

volume = "14",

pages = "1--7",

journal = "BMC Infectious Diseases",

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T1 - Neisseria meningitidis porA, fetA and fHbp gene distribution in Western Australia 2000 to 2011

AU - Boan, P.

AU - Metasan, N.

AU - Tempone, S.S.

AU - Harnett, G.B.

AU - Speers, David

AU - Keil, A.D.

PY - 2014

Y1 - 2014

N2 - © Boan et al. Background: PorA, fetA and fHbp are three antigen encoding genes useful for meningococcal typing and FHbp is an important component of meningococcal B vaccines. Methods: We performed sequence analysis of meningococcal , and genes on 128 isolates from Western Australia, relating results to age, gender, race and geographic region. Results: We found predominantly PorA subtypes P1.22,14-16 (n=23) and P1.7-2,4 (n=19); FetA subtypes F1-5 (n=41), F3-6 (n=11), F5-1 (n=10), F5-2 (n=9), F5-5 (n=8), F3-3 (n=8); and FHbp variant groups 1 (n=65) and 2 (n=44). PorA P1.22,14-16 and FHbp variant group 2 were associated with younger age and aboriginality. Conclusions: FHbp modular groups of the bivalent recombinant FHbp vaccine and the multicomponent 4CMenB vaccine make up 8.3% and 47.7% respectively of the examined serogroup B isolates from 2000-2011, however to estimate vaccine efficacy requires an account of all vaccine antigens and their levels of expression.

AB - © Boan et al. Background: PorA, fetA and fHbp are three antigen encoding genes useful for meningococcal typing and FHbp is an important component of meningococcal B vaccines. Methods: We performed sequence analysis of meningococcal , and genes on 128 isolates from Western Australia, relating results to age, gender, race and geographic region. Results: We found predominantly PorA subtypes P1.22,14-16 (n=23) and P1.7-2,4 (n=19); FetA subtypes F1-5 (n=41), F3-6 (n=11), F5-1 (n=10), F5-2 (n=9), F5-5 (n=8), F3-3 (n=8); and FHbp variant groups 1 (n=65) and 2 (n=44). PorA P1.22,14-16 and FHbp variant group 2 were associated with younger age and aboriginality. Conclusions: FHbp modular groups of the bivalent recombinant FHbp vaccine and the multicomponent 4CMenB vaccine make up 8.3% and 47.7% respectively of the examined serogroup B isolates from 2000-2011, however to estimate vaccine efficacy requires an account of all vaccine antigens and their levels of expression.

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DO - 10.1186/s12879-014-0686-x

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VL - 14

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JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

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