Background: We hypothesized that needling of a pedal wart creates local inflammation and a subsequent cell-mediated immune response (CMIR) against human papillomavirus. The primary objective of this study was to investigate whether needling to induce a CMIR against human papillomavirus is an effective treatment for pedal warts compared with liquid nitrogen cryotherapy. A secondary objective was to investigate whether the CMIR induced by needling is effective against satellite pedal warts. Methods: Eligible patients with pedal warts were randomly allocated to receive either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Follow-up was 12 weeks, with outcome assessments made independently under blinded circumstances. Results: Of 37 patients enrolled in the study, 18 were allocated to receive needling and 19 to receive liquid nitrogen cryotherapy. Regression of the primary pedal wart occurred in 64.7% of the needling group (11 of 17) and in 6.2% of the liquid nitrogen cryotherapy group (1 of 16) (P =.001). No significant relationship was found between needling of the primary pedal wart and regression of satellite pedal warts (P =.615) or complete pedal wart regression (P =.175). There was no significant difference in pain, satisfaction, or cosmesis between the two groups. Conclusions: The regression rate of the primary pedal wart was significantly higher in the needling group compared with the liquid nitrogen cryotherapy group.
|Journal||Journal of the American Podiatric Medical Association|
|Publication status||Published - 2014|
Cunningham, D. J., Brimage, J. T., Naraghi, R. N., & Bower, V. (2014). Needling versus liquid nitrogen cryotherapy for the treatment of pedal warts: A randomized controlled pilot study. Journal of the American Podiatric Medical Association, 104(4), 394-401. https://doi.org/10.7547/0003-0538-104.4.394