TY - JOUR
T1 - Needling versus liquid nitrogen cryotherapy for the treatment of pedal warts: A randomized controlled pilot study
AU - Cunningham, D.J.
AU - Brimage, J.T.
AU - Naraghi, Reza Nezami
AU - Bower, Virginia
PY - 2014
Y1 - 2014
N2 - Background: We hypothesized that needling of a pedal wart creates local inflammation and a subsequent cell-mediated immune response (CMIR) against human papillomavirus. The primary objective of this study was to investigate whether needling to induce a CMIR against human papillomavirus is an effective treatment for pedal warts compared with liquid nitrogen cryotherapy. A secondary objective was to investigate whether the CMIR induced by needling is effective against satellite pedal warts. Methods: Eligible patients with pedal warts were randomly allocated to receive either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Follow-up was 12 weeks, with outcome assessments made independently under blinded circumstances. Results: Of 37 patients enrolled in the study, 18 were allocated to receive needling and 19 to receive liquid nitrogen cryotherapy. Regression of the primary pedal wart occurred in 64.7% of the needling group (11 of 17) and in 6.2% of the liquid nitrogen cryotherapy group (1 of 16) (P =.001). No significant relationship was found between needling of the primary pedal wart and regression of satellite pedal warts (P =.615) or complete pedal wart regression (P =.175). There was no significant difference in pain, satisfaction, or cosmesis between the two groups. Conclusions: The regression rate of the primary pedal wart was significantly higher in the needling group compared with the liquid nitrogen cryotherapy group.
AB - Background: We hypothesized that needling of a pedal wart creates local inflammation and a subsequent cell-mediated immune response (CMIR) against human papillomavirus. The primary objective of this study was to investigate whether needling to induce a CMIR against human papillomavirus is an effective treatment for pedal warts compared with liquid nitrogen cryotherapy. A secondary objective was to investigate whether the CMIR induced by needling is effective against satellite pedal warts. Methods: Eligible patients with pedal warts were randomly allocated to receive either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Follow-up was 12 weeks, with outcome assessments made independently under blinded circumstances. Results: Of 37 patients enrolled in the study, 18 were allocated to receive needling and 19 to receive liquid nitrogen cryotherapy. Regression of the primary pedal wart occurred in 64.7% of the needling group (11 of 17) and in 6.2% of the liquid nitrogen cryotherapy group (1 of 16) (P =.001). No significant relationship was found between needling of the primary pedal wart and regression of satellite pedal warts (P =.615) or complete pedal wart regression (P =.175). There was no significant difference in pain, satisfaction, or cosmesis between the two groups. Conclusions: The regression rate of the primary pedal wart was significantly higher in the needling group compared with the liquid nitrogen cryotherapy group.
U2 - 10.7547/0003-0538-104.4.394
DO - 10.7547/0003-0538-104.4.394
M3 - Article
C2 - 25076084
VL - 104
SP - 394
EP - 401
JO - Journal of the American Podiatric Medical Association
JF - Journal of the American Podiatric Medical Association
SN - 1930-8264
IS - 4
ER -