Needling versus liquid nitrogen cryotherapy for the treatment of pedal warts: A randomized controlled pilot study

D.J. Cunningham, J.T. Brimage, Reza Nezami Naraghi, Virginia Bower

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    9 Citations (Scopus)


    Background: We hypothesized that needling of a pedal wart creates local inflammation and a subsequent cell-mediated immune response (CMIR) against human papillomavirus. The primary objective of this study was to investigate whether needling to induce a CMIR against human papillomavirus is an effective treatment for pedal warts compared with liquid nitrogen cryotherapy. A secondary objective was to investigate whether the CMIR induced by needling is effective against satellite pedal warts. Methods: Eligible patients with pedal warts were randomly allocated to receive either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Follow-up was 12 weeks, with outcome assessments made independently under blinded circumstances. Results: Of 37 patients enrolled in the study, 18 were allocated to receive needling and 19 to receive liquid nitrogen cryotherapy. Regression of the primary pedal wart occurred in 64.7% of the needling group (11 of 17) and in 6.2% of the liquid nitrogen cryotherapy group (1 of 16) (P =.001). No significant relationship was found between needling of the primary pedal wart and regression of satellite pedal warts (P =.615) or complete pedal wart regression (P =.175). There was no significant difference in pain, satisfaction, or cosmesis between the two groups. Conclusions: The regression rate of the primary pedal wart was significantly higher in the needling group compared with the liquid nitrogen cryotherapy group.
    Original languageEnglish
    Pages (from-to)394-401
    JournalJournal of the American Podiatric Medical Association
    Issue number4
    Publication statusPublished - 2014


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