TY - JOUR
T1 - Navigating Tumour Microenvironment and Wnt Signalling Crosstalk
T2 - Implications for Advanced Cancer Therapeutics
AU - Peri, Shraddha Shravani
AU - Narayanaa Y, Krithicaa
AU - Hubert, Therese Deebiga
AU - Rajaraman, Roshini
AU - Arfuso, Frank
AU - Sundaram, Sandhya
AU - Archana, B.
AU - Warrier, Sudha
AU - Dharmarajan, Arun
AU - Perumalsamy, Lakshmi R.
PY - 2023/12
Y1 - 2023/12
N2 - Cancer therapeutics face significant challenges due to drug resistance and tumour recurrence. The tumour microenvironment (TME) is a crucial contributor and essential hallmark of cancer. It encompasses various components surrounding the tumour, including intercellular elements, immune system cells, the vascular system, stem cells, and extracellular matrices, all of which play critical roles in tumour progression, epithelial–mesenchymal transition, metastasis, drug resistance, and relapse. These components interact with multiple signalling pathways, positively or negatively influencing cell growth. Abnormal regulation of the Wnt signalling pathway has been observed in tumorigenesis and contributes to tumour growth. A comprehensive understanding and characterisation of how different cells within the TME communicate through signalling pathways is vital. This review aims to explore the intricate and dynamic interactions, expressions, and alterations of TME components and the Wnt signalling pathway, offering valuable insights into the development of therapeutic applications.
AB - Cancer therapeutics face significant challenges due to drug resistance and tumour recurrence. The tumour microenvironment (TME) is a crucial contributor and essential hallmark of cancer. It encompasses various components surrounding the tumour, including intercellular elements, immune system cells, the vascular system, stem cells, and extracellular matrices, all of which play critical roles in tumour progression, epithelial–mesenchymal transition, metastasis, drug resistance, and relapse. These components interact with multiple signalling pathways, positively or negatively influencing cell growth. Abnormal regulation of the Wnt signalling pathway has been observed in tumorigenesis and contributes to tumour growth. A comprehensive understanding and characterisation of how different cells within the TME communicate through signalling pathways is vital. This review aims to explore the intricate and dynamic interactions, expressions, and alterations of TME components and the Wnt signalling pathway, offering valuable insights into the development of therapeutic applications.
KW - cancer stem cells
KW - cancer therapy
KW - cancer-associated adipocytes
KW - cancer-associated fibroblasts
KW - tumour microenvironment
KW - tumour vasculature
KW - tumour-activated macrophages
KW - tumour-infiltrating lymphocytes
KW - Wnt inhibitors
KW - Wnt signalling
UR - http://www.scopus.com/inward/record.url?scp=85180905459&partnerID=8YFLogxK
U2 - 10.3390/cancers15245847
DO - 10.3390/cancers15245847
M3 - Review article
C2 - 38136392
SN - 2072-6694
VL - 15
JO - Cancers
JF - Cancers
IS - 24
M1 - 5847
ER -
