TY - CHAP
T1 - Natural Insulin Sensitizers for the Management of Diabetes Mellitus
T2 - A Review of Possible Molecular Mechanisms
AU - Yaribeygi, Habib
AU - Sathyapalan, Thozhukat
AU - Jamialahmadi, Tannaz
AU - Sahebkar, Amirhossein
PY - 2021
Y1 - 2021
N2 - Diabetes mellitus is a growing health challenge globally which is increasing in epidemic proportion. Naturally occurring pharmacological agents are more likely to provide beneficial therapeutic effects without undesirable side effects compared to the synthetic agents. There is a growing evidence that some naturally occurring pharmacological agents derived from plants have potential antihyperglycemic effects. In this study, we have reviewed the molecular mechanism behind potential hypoglycemic properties of four well-known herbal-based agents, namely, ginger, curcumin, garlic, and cinnamon. Also, we present the related clinical data confirming experimental results aiming to develop novel therapeutic strategies based on these herbal agents potentially for the management of patients with diabetes.
AB - Diabetes mellitus is a growing health challenge globally which is increasing in epidemic proportion. Naturally occurring pharmacological agents are more likely to provide beneficial therapeutic effects without undesirable side effects compared to the synthetic agents. There is a growing evidence that some naturally occurring pharmacological agents derived from plants have potential antihyperglycemic effects. In this study, we have reviewed the molecular mechanism behind potential hypoglycemic properties of four well-known herbal-based agents, namely, ginger, curcumin, garlic, and cinnamon. Also, we present the related clinical data confirming experimental results aiming to develop novel therapeutic strategies based on these herbal agents potentially for the management of patients with diabetes.
KW - Cinnamon
KW - Curcumin
KW - Diabetes mellitus
KW - Garlic
KW - Ginger
KW - GLUT-4
KW - Herbal medicine
KW - Oxidative stress
KW - Pharmaceutical
UR - http://www.scopus.com/inward/record.url?scp=85122492070&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-73234-9_26
DO - 10.1007/978-3-030-73234-9_26
M3 - Chapter
C2 - 34981492
AN - SCOPUS:85122492070
SN - 978-3-030-73233-2
T3 - Advances in Experimental Medicine and Biology
SP - 401
EP - 410
BT - Natural Products and Human Diseases
A2 - Sahebkar, Amirhossein
A2 - Sathyapalan, Thozhukat
PB - Springer Heidelberg
CY - Switzerland
ER -
