Natural and artificial regulation of Arabidopsis methylome

Jonathan Boris Cahn

doi:10.4225/23/5a7a5ffb812bd

Natural and artificial regulation of Arabidopsis methylome

Jonathan Boris Cahn

School of Molecular Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

DNA methylation in Arabidopsis is commonly associated with transcriptional repression, notably of transposable elements. The presence of DNA methylation in expressed genes would however suggest that distinct molecular pathways act downstream of DNA methylation depending on its sequence context. Two approaches were used in parallel to further our understanding of how DNA methylation is interpreted at a molecular level: by attempting to artificially induce DNA methylation; and by identifying and characterizing the proteins able to bind to DNA methylation. This research highlighted a complex regulation of Arabidopsis methylome, while revealing the presence of new factors and epigenetic processes.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Lister, Ryan, Supervisor Millar, Harvey, Supervisor Small, Ian, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	19 Jan 2018
DOIs	https://doi.org/10.4225/23/5a7a5ffb812bd
Publication status	Unpublished - 2018

Embargo information

Embargoed from 28/06/2018 to 28/12/2019. Made publicly available on 28/12/2019.

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10.4225/23/5a7a5ffb812bd

THESIS - DOCTOR OF PHILOSOPHY - CAHN Jonathan Boris - 2018
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Cite this

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AB - DNA methylation in Arabidopsis is commonly associated with transcriptional repression, notably of transposable elements. The presence of DNA methylation in expressed genes would however suggest that distinct molecular pathways act downstream of DNA methylation depending on its sequence context. Two approaches were used in parallel to further our understanding of how DNA methylation is interpreted at a molecular level: by attempting to artificially induce DNA methylation; and by identifying and characterizing the proteins able to bind to DNA methylation. This research highlighted a complex regulation of Arabidopsis methylome, while revealing the presence of new factors and epigenetic processes.

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KW - Epigenetics

KW - DNA Methylation

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Natural and artificial regulation of Arabidopsis methylome

Abstract

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