Natural and artificial regulation of Arabidopsis methylome

Jonathan Boris Cahn

Research output: ThesisDoctoral Thesis

148 Downloads (Pure)

Abstract

DNA methylation in Arabidopsis is commonly associated with transcriptional repression, notably of transposable elements. The presence of DNA methylation in expressed genes would however suggest that distinct molecular pathways act downstream of DNA methylation depending on its sequence context. Two approaches were used in parallel to further our understanding of how DNA methylation is interpreted at a molecular level: by attempting to artificially induce DNA methylation; and by identifying and characterizing the proteins able to bind to DNA methylation. This research highlighted a complex regulation of Arabidopsis methylome, while revealing the presence of new factors and epigenetic processes.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lister, Ryan, Supervisor
  • Millar, Harvey, Supervisor
  • Small, Ian, Supervisor
Thesis sponsors
Award date19 Jan 2018
DOIs
Publication statusUnpublished - 2018

Fingerprint

DNA methylation
Arabidopsis
epigenetics
transposons
genes
proteins

Bibliographical note

Embargoed from 28/06/2018 to 28/12/2019
Made publicly available on 28/12/2019

Cite this

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Cahn, JB 2018, 'Natural and artificial regulation of Arabidopsis methylome', Doctor of Philosophy, The University of Western Australia. https://doi.org/10.4225/23/5a7a5ffb812bd

Natural and artificial regulation of Arabidopsis methylome. / Cahn, Jonathan Boris.

2018.

Research output: ThesisDoctoral Thesis

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AB - DNA methylation in Arabidopsis is commonly associated with transcriptional repression, notably of transposable elements. The presence of DNA methylation in expressed genes would however suggest that distinct molecular pathways act downstream of DNA methylation depending on its sequence context. Two approaches were used in parallel to further our understanding of how DNA methylation is interpreted at a molecular level: by attempting to artificially induce DNA methylation; and by identifying and characterizing the proteins able to bind to DNA methylation. This research highlighted a complex regulation of Arabidopsis methylome, while revealing the presence of new factors and epigenetic processes.

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KW - Epigenetics

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