DNA methylation in Arabidopsis is commonly associated with transcriptional repression, notably of transposable elements. The presence of DNA methylation in expressed genes would however suggest that distinct molecular pathways act downstream of DNA methylation depending on its sequence context. Two approaches were used in parallel to further our understanding of how DNA methylation is interpreted at a molecular level: by attempting to artificially induce DNA methylation; and by identifying and characterizing the proteins able to bind to DNA methylation. This research highlighted a complex regulation of Arabidopsis methylome, while revealing the presence of new factors and epigenetic processes.
|Qualification||Doctor of Philosophy|
|Award date||19 Jan 2018|
|Publication status||Unpublished - 2018|
Take-down noticeEmbargoed from 28/06/2018 to 28/12/2019
Made publicly available on 28/12/2019