Narrow Band Imaging-guided resection of oral cavity cancer decreases local recurrence and increases survival

C. S. Farah

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: Overall local recurrence of oral squamous cell carcinoma (OSCC) is estimated at 20%. Incomplete primary tumour excision contributes to localised postsurgical recurrence of OSCC. The purpose of this study was to report on patient outcomes following resection of OSCC using Narrow Band Imaging (NBI). Materials and Methods: Patients with OSCC requiring resection were visualised under conventional white light (WL) then NBI using an Olympus NBI ENF-VQ nasendoscope with CLV-180 light source and processor (Olympus Medical Systems, Tokyo, Japan). OSCC tissue was resected to the NBI-defined surgical margins, and patients followed for a minimum of 5 years postsurgery to assess local recurrence rate (LRR) and disease-free survival (DFS). Results: Of the 20 patients recruited for this study, one patient (5%) declined follow-up. At the latest follow-up period (up to 7 years postsurgery), 14 of 19 patients (73.68%) were alive with no recurrence. Two patients (10.53%) had died from metastatic disease with no local recurrence, one patient (5.26%) had died from disease with local recurrence, and two patients (10.53%) had died disease-free from other causes. In total, 16 of 19 patients (84.21%) who were followed for a minimum of 5 years were still alive and had not developed local recurrence. Only one patient developed local recurrence. Five-year DFS was 84.21% and LRR was 5.26%. Conclusion: Resection to NBI-defined margins improves survival rates and decreases recurrence rates of OSCC compared to traditional methods and should be adopted as the new gold standard for determining mucosal surgical margins for treatment of oral cavity cancer. These promising results have set the scene for a multicentred randomised controlled trial comparing NBI to WL currently underway.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalOral Diseases
Volume24
Issue number1-2
DOIs
Publication statusPublished - 1 Mar 2018

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Narrow Band Imaging
Mouth Neoplasms
Mouth
Recurrence
Survival
Squamous Cell Carcinoma
Light
Disease-Free Survival
Tokyo
Japan

Cite this

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title = "Narrow Band Imaging-guided resection of oral cavity cancer decreases local recurrence and increases survival",
abstract = "Purpose: Overall local recurrence of oral squamous cell carcinoma (OSCC) is estimated at 20{\%}. Incomplete primary tumour excision contributes to localised postsurgical recurrence of OSCC. The purpose of this study was to report on patient outcomes following resection of OSCC using Narrow Band Imaging (NBI). Materials and Methods: Patients with OSCC requiring resection were visualised under conventional white light (WL) then NBI using an Olympus NBI ENF-VQ nasendoscope with CLV-180 light source and processor (Olympus Medical Systems, Tokyo, Japan). OSCC tissue was resected to the NBI-defined surgical margins, and patients followed for a minimum of 5 years postsurgery to assess local recurrence rate (LRR) and disease-free survival (DFS). Results: Of the 20 patients recruited for this study, one patient (5{\%}) declined follow-up. At the latest follow-up period (up to 7 years postsurgery), 14 of 19 patients (73.68{\%}) were alive with no recurrence. Two patients (10.53{\%}) had died from metastatic disease with no local recurrence, one patient (5.26{\%}) had died from disease with local recurrence, and two patients (10.53{\%}) had died disease-free from other causes. In total, 16 of 19 patients (84.21{\%}) who were followed for a minimum of 5 years were still alive and had not developed local recurrence. Only one patient developed local recurrence. Five-year DFS was 84.21{\%} and LRR was 5.26{\%}. Conclusion: Resection to NBI-defined margins improves survival rates and decreases recurrence rates of OSCC compared to traditional methods and should be adopted as the new gold standard for determining mucosal surgical margins for treatment of oral cavity cancer. These promising results have set the scene for a multicentred randomised controlled trial comparing NBI to WL currently underway.",
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Narrow Band Imaging-guided resection of oral cavity cancer decreases local recurrence and increases survival. / Farah, C. S.

In: Oral Diseases, Vol. 24, No. 1-2, 01.03.2018, p. 89-97.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Narrow Band Imaging-guided resection of oral cavity cancer decreases local recurrence and increases survival

AU - Farah, C. S.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Purpose: Overall local recurrence of oral squamous cell carcinoma (OSCC) is estimated at 20%. Incomplete primary tumour excision contributes to localised postsurgical recurrence of OSCC. The purpose of this study was to report on patient outcomes following resection of OSCC using Narrow Band Imaging (NBI). Materials and Methods: Patients with OSCC requiring resection were visualised under conventional white light (WL) then NBI using an Olympus NBI ENF-VQ nasendoscope with CLV-180 light source and processor (Olympus Medical Systems, Tokyo, Japan). OSCC tissue was resected to the NBI-defined surgical margins, and patients followed for a minimum of 5 years postsurgery to assess local recurrence rate (LRR) and disease-free survival (DFS). Results: Of the 20 patients recruited for this study, one patient (5%) declined follow-up. At the latest follow-up period (up to 7 years postsurgery), 14 of 19 patients (73.68%) were alive with no recurrence. Two patients (10.53%) had died from metastatic disease with no local recurrence, one patient (5.26%) had died from disease with local recurrence, and two patients (10.53%) had died disease-free from other causes. In total, 16 of 19 patients (84.21%) who were followed for a minimum of 5 years were still alive and had not developed local recurrence. Only one patient developed local recurrence. Five-year DFS was 84.21% and LRR was 5.26%. Conclusion: Resection to NBI-defined margins improves survival rates and decreases recurrence rates of OSCC compared to traditional methods and should be adopted as the new gold standard for determining mucosal surgical margins for treatment of oral cavity cancer. These promising results have set the scene for a multicentred randomised controlled trial comparing NBI to WL currently underway.

AB - Purpose: Overall local recurrence of oral squamous cell carcinoma (OSCC) is estimated at 20%. Incomplete primary tumour excision contributes to localised postsurgical recurrence of OSCC. The purpose of this study was to report on patient outcomes following resection of OSCC using Narrow Band Imaging (NBI). Materials and Methods: Patients with OSCC requiring resection were visualised under conventional white light (WL) then NBI using an Olympus NBI ENF-VQ nasendoscope with CLV-180 light source and processor (Olympus Medical Systems, Tokyo, Japan). OSCC tissue was resected to the NBI-defined surgical margins, and patients followed for a minimum of 5 years postsurgery to assess local recurrence rate (LRR) and disease-free survival (DFS). Results: Of the 20 patients recruited for this study, one patient (5%) declined follow-up. At the latest follow-up period (up to 7 years postsurgery), 14 of 19 patients (73.68%) were alive with no recurrence. Two patients (10.53%) had died from metastatic disease with no local recurrence, one patient (5.26%) had died from disease with local recurrence, and two patients (10.53%) had died disease-free from other causes. In total, 16 of 19 patients (84.21%) who were followed for a minimum of 5 years were still alive and had not developed local recurrence. Only one patient developed local recurrence. Five-year DFS was 84.21% and LRR was 5.26%. Conclusion: Resection to NBI-defined margins improves survival rates and decreases recurrence rates of OSCC compared to traditional methods and should be adopted as the new gold standard for determining mucosal surgical margins for treatment of oral cavity cancer. These promising results have set the scene for a multicentred randomised controlled trial comparing NBI to WL currently underway.

KW - 5-year survival

KW - local recurrence

KW - molecular margins

KW - Narrow Band Imaging

KW - oral cavity cancer

KW - oral squamous cell carcinoma

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U2 - 10.1111/odi.12745

DO - 10.1111/odi.12745

M3 - Article

VL - 24

SP - 89

EP - 97

JO - Oral Diseases

JF - Oral Diseases

SN - 1354-523X

IS - 1-2

ER -