Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy

Naresh Kumar, Marek M. Drozdz, Haibo Jiang, Daniela M. Santos, David J. Vaux

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre-adipocyte cell is mapped with <20 nm spatial resolution, overcoming the diffraction limit of confocal Raman spectroscopy via plasmonic enhancement of Raman signals at a TERS tip-apex.

Original languageEnglish
Pages (from-to)2451-2454
Number of pages4
JournalChemical Communications
Volume53
Issue number16
DOIs
Publication statusPublished - 2017

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