Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy

Naresh Kumar; Marek M. Drozdz; Haibo Jiang; Daniela M. Santos; David J. Vaux

doi:10.1039/c6cc10226c

Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy

Naresh Kumar, Marek M. Drozdz, Haibo Jiang, Daniela M. Santos, David J. Vaux

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre-adipocyte cell is mapped with <20 nm spatial resolution, overcoming the diffraction limit of confocal Raman spectroscopy via plasmonic enhancement of Raman signals at a TERS tip-apex.

Original language	English
Pages (from-to)	2451-2454
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	16
DOIs	https://doi.org/10.1039/c6cc10226c
Publication status	Published - 2017

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10.1039/c6cc10226cLicence: CC BY

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AU - Vaux, David J.

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AB - Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre-adipocyte cell is mapped with <20 nm spatial resolution, overcoming the diffraction limit of confocal Raman spectroscopy via plasmonic enhancement of Raman signals at a TERS tip-apex.

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Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy

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