Nanoparticle-mediated internalisation and release of a calcium channel blocker

Cameron Evans; Helena Viola; D. Ho; Livia Hool; Sarah Dunlop; Melinda Fitzgerald; Killugudi Swaminatha Iyer

doi:10.1039/c2ra21058d

Nanoparticle-mediated internalisation and release of a calcium channel blocker

Cameron Evans
, Helena Viola
, D. Ho
, Livia Hool
, Sarah Dunlop
, Melinda Fitzgerald
, Killugudi Swaminatha Iyer

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Lomerizine is a calcium channel blocker that selectively blocks L- and T-type Ca2+ channels, but it is effectively insoluble under physiological conditions. Herein we show that lomerizine can be released from a nanoparticle-based carrier by intracellular protonation in PC12 cells, suppressing Ca2+ influx in these cells in response to glutamate.

Original language	English
Pages (from-to)	8587-8590
Journal	RSC Advances
Volume	2
Early online date	25 Jul 2012
DOIs	https://doi.org/10.1039/c2ra21058d
Publication status	Published - 2012

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10.1039/c2ra21058d

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title = "Nanoparticle-mediated internalisation and release of a calcium channel blocker",

abstract = "Lomerizine is a calcium channel blocker that selectively blocks L- and T-type Ca2+ channels, but it is effectively insoluble under physiological conditions. Herein we show that lomerizine can be released from a nanoparticle-based carrier by intracellular protonation in PC12 cells, suppressing Ca2+ influx in these cells in response to glutamate.",

author = "Cameron Evans and Helena Viola and D. Ho and Livia Hool and Sarah Dunlop and Melinda Fitzgerald and \{Swaminatha Iyer\}, Killugudi",

year = "2012",

doi = "10.1039/c2ra21058d",

language = "English",

volume = "2",

pages = "8587--8590",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "ROYAL SOC CHEMISTRY",

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T1 - Nanoparticle-mediated internalisation and release of a calcium channel blocker

AU - Evans, Cameron

AU - Viola, Helena

AU - Ho, D.

AU - Hool, Livia

AU - Dunlop, Sarah

AU - Fitzgerald, Melinda

AU - Swaminatha Iyer, Killugudi

PY - 2012

Y1 - 2012

N2 - Lomerizine is a calcium channel blocker that selectively blocks L- and T-type Ca2+ channels, but it is effectively insoluble under physiological conditions. Herein we show that lomerizine can be released from a nanoparticle-based carrier by intracellular protonation in PC12 cells, suppressing Ca2+ influx in these cells in response to glutamate.

AB - Lomerizine is a calcium channel blocker that selectively blocks L- and T-type Ca2+ channels, but it is effectively insoluble under physiological conditions. Herein we show that lomerizine can be released from a nanoparticle-based carrier by intracellular protonation in PC12 cells, suppressing Ca2+ influx in these cells in response to glutamate.

U2 - 10.1039/c2ra21058d

DO - 10.1039/c2ra21058d

M3 - Article

SN - 2046-2069

VL - 2

SP - 8587

EP - 8590

JO - RSC Advances

JF - RSC Advances

ER -

Nanoparticle-mediated internalisation and release of a calcium channel blocker

Abstract

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