Nanoparticle-mediated internalisation and release of a calcium channel blocker

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9 Citations (Scopus)


Lomerizine is a calcium channel blocker that selectively blocks L- and T-type Ca2+ channels, but it is effectively insoluble under physiological conditions. Herein we show that lomerizine can be released from a nanoparticle-based carrier by intracellular protonation in PC12 cells, suppressing Ca2+ influx in these cells in response to glutamate.
Original languageEnglish
Pages (from-to)8587-8590
JournalRSC Advances
Early online date25 Jul 2012
Publication statusPublished - 2012


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