Curcumin extracted from the rhizomes of Curcuma longa and widely used because of its biological advantages such as anti-inflammatory, anti-cancer, anti-oxidant, anti-ageing, anti-microbial, and wound healing. A wide range of diseases can be diagnosed with the help of curcumin nanoformulations, which have profoundly impacted the pharmaceutical industry. For instance, the anti-cancer effects of curcumin are a highlighted side of curcumin's therapeutic effects. Curcumin, a natural phytochemical agent, can provide an adjuvant when combined with radiotherapy and chemotherapy. Although the unique properties of curcumin make this bioactive substance a versatile therapeutic agent, the lack of appropriate formulation limited the clinical and pharmaceutical application of curcumin. Emerging nanotechnology, particularly nanoparticles, can solve chemical therapy's limitations thanks to its ability to entrap poorly soluble drugs for administration, enhance internalization, and reduce side effects. Among different nanoparticles, nanogels (NGs) with three-dimensional nanonetwork structures and capability covering Both hydrogels and nanoparticles properties could overcome various usual limitations of nanoparticles and enhance the local and systemic drug delivery. Another possible carrier for curcumin is nanodiscs (NDs). NDs which are not spherical, have been paid considerable attention. The concept of the ND constitution is derived from biologically-derived solutions for transferring lipids in the bloodstream. Furthermore, several studies have investigated the efficiency and dependability of curcumin distribution with yeast-based frameworks. Lastly, complex curcumin with transition metals boosts the pharmacological effects of this bioactive molecule, and it is therefore required to raise its bioavailability and solubility in water. In this chapter, we will review the application of NGs, NDs, Yeast cells, and metallo-complexes-based materials in curcumin delivery and briefly evaluate their potential benefits for enhancing curcumin application in the pharmaceutical and clinical setting.