TY - JOUR
T1 - Naive and Memory CD4+ T Cells Are Differentially Affected in Indonesian HIV Patients Responding to ART
AU - Tanaskovic, Sara
AU - Fernandez, Sonia
AU - Saraswati, H.
AU - Yunihastuti, E.
AU - Gani, R.A.
AU - Djauzi, S.
AU - Price, P.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - © Copyright 2016, Mary Ann Liebert, Inc. 2016. While most HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency recover CD4+ T cell numbers, the profiles and functions of the newly acquired CD4+ T cells have not been monitored in a resource-limiting setting. In this study, HIV patients (n = 31) from Jakarta, Indonesia, were studied 9 months after commencing ART with nadir CD4+ T cell counts 200 cells/μL over 12 months. At 9 months, patients had fewer naive and CD31+-naive CD4+ T cells, more effector memory (EM) CD4+ T cells, and higher HLA-DR expression on CD4+ T cells than controls. CD127 expression was low on all CD4+ T cell subsets except for naive cells, where it was similar to controls. Similarly, after anti-CD3 antibody or IL-7 stimulation, patients had lower Ki67 expression than controls in all subsets, except naive CD4+ T cells where it was normal or elevated. Overall in the first year of ART, patients had fewer naive and more EM CD4+ T cells. Ongoing immune activation and, antigen-driven stimulation and differentiation of naive T cells may reduce the naive T cell pool, while driving the maturation and accumulation of memory cells with proliferative defects.
AB - © Copyright 2016, Mary Ann Liebert, Inc. 2016. While most HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency recover CD4+ T cell numbers, the profiles and functions of the newly acquired CD4+ T cells have not been monitored in a resource-limiting setting. In this study, HIV patients (n = 31) from Jakarta, Indonesia, were studied 9 months after commencing ART with nadir CD4+ T cell counts 200 cells/μL over 12 months. At 9 months, patients had fewer naive and CD31+-naive CD4+ T cells, more effector memory (EM) CD4+ T cells, and higher HLA-DR expression on CD4+ T cells than controls. CD127 expression was low on all CD4+ T cell subsets except for naive cells, where it was similar to controls. Similarly, after anti-CD3 antibody or IL-7 stimulation, patients had lower Ki67 expression than controls in all subsets, except naive CD4+ T cells where it was normal or elevated. Overall in the first year of ART, patients had fewer naive and more EM CD4+ T cells. Ongoing immune activation and, antigen-driven stimulation and differentiation of naive T cells may reduce the naive T cell pool, while driving the maturation and accumulation of memory cells with proliferative defects.
U2 - 10.1089/vim.2015.0108
DO - 10.1089/vim.2015.0108
M3 - Article
C2 - 27035638
SN - 0882-8245
VL - 29
SP - 176
EP - 183
JO - Viral Immunology
JF - Viral Immunology
IS - 3
ER -