Naive and Memory CD4+ T Cells Are Differentially Affected in Indonesian HIV Patients Responding to ART

Sara Tanaskovic, Sonia Fernandez, H. Saraswati, E. Yunihastuti, R.A. Gani, S. Djauzi, P. Price

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    © Copyright 2016, Mary Ann Liebert, Inc. 2016. While most HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency recover CD4+ T cell numbers, the profiles and functions of the newly acquired CD4+ T cells have not been monitored in a resource-limiting setting. In this study, HIV patients (n = 31) from Jakarta, Indonesia, were studied 9 months after commencing ART with nadir CD4+ T cell counts 200 cells/μL over 12 months. At 9 months, patients had fewer naive and CD31+-naive CD4+ T cells, more effector memory (EM) CD4+ T cells, and higher HLA-DR expression on CD4+ T cells than controls. CD127 expression was low on all CD4+ T cell subsets except for naive cells, where it was similar to controls. Similarly, after anti-CD3 antibody or IL-7 stimulation, patients had lower Ki67 expression than controls in all subsets, except naive CD4+ T cells where it was normal or elevated. Overall in the first year of ART, patients had fewer naive and more EM CD4+ T cells. Ongoing immune activation and, antigen-driven stimulation and differentiation of naive T cells may reduce the naive T cell pool, while driving the maturation and accumulation of memory cells with proliferative defects.
    Original languageEnglish
    Pages (from-to)176-183
    JournalViral Immunology
    Volume29
    Issue number3
    DOIs
    Publication statusPublished - 2016

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