Myopia is associated with lower vitamin D status in young adults

S. Yazar, Alex Hewitt, Lucinda Black, C.M. Mcknight, Jenny Mountain, Justin Sherwin, Wendy Oddy, M.T.C. Coroneo, Robyn Lucas, David Mackey

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91 Citations (Scopus)


Purpose. To investigate the association between serum vitamin D levels and myopia in young adults. Methods. A total of 946 individuals participating in the 20-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study were included in this study. Ethnicity, parental myopia, and education status were ascertained by self-reported questionnaire. A comprehensive ophthalmic examination was performed, including postcycloplegic autorefraction and conjunctival UV autofluorescence photography. Serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations were determined using mass spectrometry. The association between serum 25(OH)D3 concentrations and prevalent myopia was determined using multivariable logistic regression. Myopia was defined as mean spherical equivalent ≤ -0.5 diopters. Results. Of the 946 participants, 221 (23.4%) had myopia (n = 725 nonmyopic). Myopic subjects had lower serum 25(OH)D3 concentrations compared to nonmyopic participants (median 67.6 vs. 72.5 nmol, P = 0.003). In univariable analysis, lower serum 25(OH)D3 concentration was associated with higher risk of having myopia (odds ratio [OR] for
Original languageEnglish
Pages (from-to)4552-4559
JournalInvestigative Ophthalmology and Visual Science
Issue number7
Publication statusPublished - Jul 2014


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