Myopia is associated with lower vitamin D status in young adults

S. Yazar; Alex Hewitt; Lucinda Black; C.M. Mcknight; Jenny Mountain; Justin Sherwin; Wendy Oddy; M.T.C. Coroneo; Robyn Lucas; David Mackey

doi:10.1167/iovs.14-14589

Myopia is associated with lower vitamin D status in young adults

S. Yazar, Alex Hewitt, Lucinda Black, C.M. Mcknight, Jenny Mountain, Justin Sherwin, Wendy Oddy, M.T.C. Coroneo, Robyn Lucas, David Mackey

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Abstract

Purpose. To investigate the association between serum vitamin D levels and myopia in young adults. Methods. A total of 946 individuals participating in the 20-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study were included in this study. Ethnicity, parental myopia, and education status were ascertained by self-reported questionnaire. A comprehensive ophthalmic examination was performed, including postcycloplegic autorefraction and conjunctival UV autofluorescence photography. Serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations were determined using mass spectrometry. The association between serum 25(OH)D3 concentrations and prevalent myopia was determined using multivariable logistic regression. Myopia was defined as mean spherical equivalent ≤ -0.5 diopters. Results. Of the 946 participants, 221 (23.4%) had myopia (n = 725 nonmyopic). Myopic subjects had lower serum 25(OH)D3 concentrations compared to nonmyopic participants (median 67.6 vs. 72.5 nmol, P = 0.003). In univariable analysis, lower serum 25(OH)D3 concentration was associated with higher risk of having myopia (odds ratio [OR] for

Original language	English
Pages (from-to)	4552-4559
Journal	Investigative Ophthalmology and Visual Science
Volume	55
Issue number	7
DOIs	https://doi.org/10.1167/iovs.14-14589
Publication status	Published - Jul 2014

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title = "Myopia is associated with lower vitamin D status in young adults",

abstract = "Purpose. To investigate the association between serum vitamin D levels and myopia in young adults. Methods. A total of 946 individuals participating in the 20-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study were included in this study. Ethnicity, parental myopia, and education status were ascertained by self-reported questionnaire. A comprehensive ophthalmic examination was performed, including postcycloplegic autorefraction and conjunctival UV autofluorescence photography. Serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations were determined using mass spectrometry. The association between serum 25(OH)D3 concentrations and prevalent myopia was determined using multivariable logistic regression. Myopia was defined as mean spherical equivalent ≤ -0.5 diopters. Results. Of the 946 participants, 221 (23.4%) had myopia (n = 725 nonmyopic). Myopic subjects had lower serum 25(OH)D3 concentrations compared to nonmyopic participants (median 67.6 vs. 72.5 nmol, P = 0.003). In univariable analysis, lower serum 25(OH)D3 concentration was associated with higher risk of having myopia (odds ratio [OR] for",

author = "S. Yazar and Alex Hewitt and Lucinda Black and C.M. Mcknight and Jenny Mountain and Justin Sherwin and Wendy Oddy and M.T.C. Coroneo and Robyn Lucas and David Mackey",

year = "2014",

month = jul,

doi = "10.1167/iovs.14-14589",

language = "English",

volume = "55",

pages = "4552--4559",

journal = "Investigative Ophthalmology and Visual Science",

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TY - JOUR

T1 - Myopia is associated with lower vitamin D status in young adults

AU - Yazar, S.

AU - Hewitt, Alex

AU - Black, Lucinda

AU - Mcknight, C.M.

AU - Mountain, Jenny

AU - Sherwin, Justin

AU - Oddy, Wendy

AU - Coroneo, M.T.C.

AU - Lucas, Robyn

AU - Mackey, David

PY - 2014/7

Y1 - 2014/7

N2 - Purpose. To investigate the association between serum vitamin D levels and myopia in young adults. Methods. A total of 946 individuals participating in the 20-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study were included in this study. Ethnicity, parental myopia, and education status were ascertained by self-reported questionnaire. A comprehensive ophthalmic examination was performed, including postcycloplegic autorefraction and conjunctival UV autofluorescence photography. Serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations were determined using mass spectrometry. The association between serum 25(OH)D3 concentrations and prevalent myopia was determined using multivariable logistic regression. Myopia was defined as mean spherical equivalent ≤ -0.5 diopters. Results. Of the 946 participants, 221 (23.4%) had myopia (n = 725 nonmyopic). Myopic subjects had lower serum 25(OH)D3 concentrations compared to nonmyopic participants (median 67.6 vs. 72.5 nmol, P = 0.003). In univariable analysis, lower serum 25(OH)D3 concentration was associated with higher risk of having myopia (odds ratio [OR] for

AB - Purpose. To investigate the association between serum vitamin D levels and myopia in young adults. Methods. A total of 946 individuals participating in the 20-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study were included in this study. Ethnicity, parental myopia, and education status were ascertained by self-reported questionnaire. A comprehensive ophthalmic examination was performed, including postcycloplegic autorefraction and conjunctival UV autofluorescence photography. Serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations were determined using mass spectrometry. The association between serum 25(OH)D3 concentrations and prevalent myopia was determined using multivariable logistic regression. Myopia was defined as mean spherical equivalent ≤ -0.5 diopters. Results. Of the 946 participants, 221 (23.4%) had myopia (n = 725 nonmyopic). Myopic subjects had lower serum 25(OH)D3 concentrations compared to nonmyopic participants (median 67.6 vs. 72.5 nmol, P = 0.003). In univariable analysis, lower serum 25(OH)D3 concentration was associated with higher risk of having myopia (odds ratio [OR] for

U2 - 10.1167/iovs.14-14589

DO - 10.1167/iovs.14-14589

M3 - Article

SN - 0146-0404

VL - 55

SP - 4552

EP - 4559

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 7

ER -

Myopia is associated with lower vitamin D status in young adults

Abstract

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