Myocardial water handling and the role of aquaporins

Jonathan R. Egan, Tanya L. Butler, Carol G. Au, Yee Mun Tan, Kathryn N. North, David S. Winlaw

Research output: Contribution to journalReview articlepeer-review

49 Citations (Scopus)


Cardiac surgery is performed in approximately 770,000 adults and 30,000 children in the United States of America annually. In this review we outline the mechanistic links between post-operative myocardial stunning and the development of myocardial edema. These interrelated processes cause a decline in myocardial performance that account for significant morbidity and mortality after cardiac surgery. Factors leading to myocardial edema include hemodilution, ischemia and reperfusion as well as osmotic gradients arising from pathological change. Several members of the aquaporin family of water transport proteins have been described in the myocardium although their role in the pathogenesis and resolution of cardiac edema is not established. This review examines evidence for the involvement of aquaporins in myocardial water handling during normal and pathological conditions.

Original languageEnglish
Pages (from-to)1043-1052
Number of pages10
JournalBiochimica et Biophysica Acta - Biomembranes
Issue number8
Publication statusPublished - Aug 2006
Externally publishedYes


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