Multipotent pancreas progenitors: Inconclusive but pivotal topic

Research output: Contribution to journalArticlepeer-review

6 Citations (Web of Science)


The establishment of multipotent pancreas progenitors (MPP) should have a significant impact not only on the ontology of the pancreas, but also for the translational research of glucose-responding endocrine β-cells. Deficiency of the latter may lead to the pandemic type 1 or type 2 diabetes mellitus, a metabolic disorder. An ideal treatment of which would potentially be the replacement of destroyed or failed β-cells, by restoring function of endogenous pancreatic endocrine cells or by transplantation of donor islets or in vitro generated insulin-secreting cells. Thus, considerable research efforts have been devoted to identify MPP candidates in the pre- and post-natal pancreas for the endogenous neogenesis or regeneration of endocrine insulin-secreting cells. In order to advance this inconclusive but critical field, we here review the emerging concepts, recent literature and newest developments of potential MPP and propose measures that would assist its forward progression.
Original languageEnglish
Pages (from-to)1251-1261
Number of pages11
JournalWorld Journal of Stem Cells
Issue number11
Publication statusPublished - 26 Dec 2015


Dive into the research topics of 'Multipotent pancreas progenitors: Inconclusive but pivotal topic'. Together they form a unique fingerprint.

Cite this