Multiplex Testing of the Effect of Statins on Disease Severity Risk in COVID-19 Cases

Fatemeh Zahedipour; Paul C. Guest; Muhammed Majeed; Khalid Al-Rasadi; Tannaz Jamialahmadi; Amirhossein Sahebkar

doi:10.1007/978-1-0716-2395-4_20

Multiplex Testing of the Effect of Statins on Disease Severity Risk in COVID-19 Cases

Fatemeh Zahedipour
, Paul C. Guest
, Muhammed Majeed
, Khalid Al-Rasadi
, Tannaz Jamialahmadi
, Amirhossein Sahebkar

UWA Medical School

Research output: Chapter in Book/Conference paper › Chapter › peer-review

Abstract

Statins have pleiotropic effects on inflammatory responses in addition to their lipid-lowering action, which contributes to their favorable effect on cardiovascular disorders. Statins affect adhesion, migration, antigen presentation, and cytokine generation of immune cells. Pre-clinical and clinical studies suggest that statin intervention targeted early in the infection might help COVID-19 patients to reduce the effects of acute respiratory distress syndrome (ARDS), the cytokine storm, and vascular collapse by modulating harmful pathogenic mechanisms. This chapter presents a protocol for measuring blood-based biomarkers predictive of these responses in COVID-19 patients using two specific multiplex immunoassays that target proteins that differ widely in concentration.

Original language	English
Title of host publication	Methods in Molecular Biology
Editors	Paul Guest
Publisher	Humana Press Inc.
Pages	273-284
Number of pages	12
DOIs	https://doi.org/10.1007/978-1-0716-2395-4_20
Publication status	Published - 2022

Publication series

Name	Methods in Molecular Biology
Volume	2511
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/978-1-0716-2395-4_20

Cite this

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title = "Multiplex Testing of the Effect of Statins on Disease Severity Risk in COVID-19 Cases",

abstract = "Statins have pleiotropic effects on inflammatory responses in addition to their lipid-lowering action, which contributes to their favorable effect on cardiovascular disorders. Statins affect adhesion, migration, antigen presentation, and cytokine generation of immune cells. Pre-clinical and clinical studies suggest that statin intervention targeted early in the infection might help COVID-19 patients to reduce the effects of acute respiratory distress syndrome (ARDS), the cytokine storm, and vascular collapse by modulating harmful pathogenic mechanisms. This chapter presents a protocol for measuring blood-based biomarkers predictive of these responses in COVID-19 patients using two specific multiplex immunoassays that target proteins that differ widely in concentration.",

keywords = "C-reactive protein, COVID-19, IL-6, IL-8, Multiplex immunoassay, SARS-CoV-2, Simvastatin, Statins, TNF-α, Von Willebrand factor",

author = "Fatemeh Zahedipour and Guest, \{Paul C.\} and Muhammed Majeed and Khalid Al-Rasadi and Tannaz Jamialahmadi and Amirhossein Sahebkar",

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doi = "10.1007/978-1-0716-2395-4\_20",

language = "English",

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publisher = "Humana Press Inc.",

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T1 - Multiplex Testing of the Effect of Statins on Disease Severity Risk in COVID-19 Cases

AU - Zahedipour, Fatemeh

AU - Guest, Paul C.

AU - Majeed, Muhammed

AU - Al-Rasadi, Khalid

AU - Jamialahmadi, Tannaz

AU - Sahebkar, Amirhossein

PY - 2022

Y1 - 2022

N2 - Statins have pleiotropic effects on inflammatory responses in addition to their lipid-lowering action, which contributes to their favorable effect on cardiovascular disorders. Statins affect adhesion, migration, antigen presentation, and cytokine generation of immune cells. Pre-clinical and clinical studies suggest that statin intervention targeted early in the infection might help COVID-19 patients to reduce the effects of acute respiratory distress syndrome (ARDS), the cytokine storm, and vascular collapse by modulating harmful pathogenic mechanisms. This chapter presents a protocol for measuring blood-based biomarkers predictive of these responses in COVID-19 patients using two specific multiplex immunoassays that target proteins that differ widely in concentration.

AB - Statins have pleiotropic effects on inflammatory responses in addition to their lipid-lowering action, which contributes to their favorable effect on cardiovascular disorders. Statins affect adhesion, migration, antigen presentation, and cytokine generation of immune cells. Pre-clinical and clinical studies suggest that statin intervention targeted early in the infection might help COVID-19 patients to reduce the effects of acute respiratory distress syndrome (ARDS), the cytokine storm, and vascular collapse by modulating harmful pathogenic mechanisms. This chapter presents a protocol for measuring blood-based biomarkers predictive of these responses in COVID-19 patients using two specific multiplex immunoassays that target proteins that differ widely in concentration.

KW - C-reactive protein

KW - COVID-19

KW - IL-6

KW - IL-8

KW - Multiplex immunoassay

KW - SARS-CoV-2

KW - Simvastatin

KW - Statins

KW - TNF-α

KW - Von Willebrand factor

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U2 - 10.1007/978-1-0716-2395-4_20

DO - 10.1007/978-1-0716-2395-4_20

M3 - Chapter

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AN - SCOPUS:85134588332

T3 - Methods in Molecular Biology

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BT - Methods in Molecular Biology

A2 - Guest, Paul

PB - Humana Press Inc.

ER -

Multiplex Testing of the Effect of Statins on Disease Severity Risk in COVID-19 Cases

Abstract

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UN SDGs

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