Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Int Multiple Sclerosis Genetics Co; Int Multiple Sclerosis Genetics Co; ANZgene; IIBDGC; Australia New Zealand IBDGC; Belgium Genetic Consortiumt; Initiative Crohn Colitis; NIDDK IBDGCJ; United Kingdom IBDGC; Wellcome Trust Case Control Conso; WTCCC2

doi:10.1126/science.aav7188

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Int Multiple Sclerosis Genetics Co, Int Multiple Sclerosis Genetics Co, ANZgene, IIBDGC, Australia New Zealand IBDGC, Belgium Genetic Consortiumt, Initiative Crohn Colitis, NIDDK IBDGCJ, United Kingdom IBDGC, Wellcome Trust Case Control Conso, WTCCC2

Research output: Contribution to journal › Article › peer-review

858 Citations (Scopus)

Original language	English
Article number	eaav7188
Pages (from-to)	1417-+
Number of pages	99
Journal	Science
Volume	365
Issue number	6460
DOIs	https://doi.org/10.1126/science.aav7188
Publication status	Published - 27 Sept 2019

Access to Document

10.1126/science.aav7188

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241648/

Cite this

Int Multiple Sclerosis Genetics Co, Int Multiple Sclerosis Genetics Co, ANZgene, IIBDGC, Australia New Zealand IBDGC, Belgium Genetic Consortiumt, Initiative Crohn Colitis, NIDDK IBDGCJ, United Kingdom IBDGC, Wellcome Trust Case Control Conso, & WTCCC2 (2019). Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science, 365(6460), 1417-+. Article eaav7188. https://doi.org/10.1126/science.aav7188

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title = "Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility",

keywords = "GENE-EXPRESSION, DIAGNOSTIC-CRITERIA, COMPLEX TRAITS, RISK ALLELES, ASSOCIATION, AUTOIMMUNE, HERITABILITY, ARCHITECTURE, METAANALYSIS, MECHANISMS",

author = "{Int Multiple Sclerosis Genetics Co} and {Int Multiple Sclerosis Genetics Co} and ANZgene and IIBDGC and {Australia New Zealand IBDGC} and {Belgium Genetic Consortiumt} and {Initiative Crohn Colitis} and {NIDDK IBDGCJ} and {United Kingdom IBDGC} and {Wellcome Trust Case Control Conso} and WTCCC2 and Patsopoulos, {Nikolas A.} and Baranzini, {Sergio E.} and Adams Santaniello and Parisa Shoostari and Chris Cotsapas and Garrett Wong and Beecham, {Ashley H.} and Tojo James and Joseph Replogle and Vlachos, {Ioannis S.} and Cristin McCabe and Pers, {Tune H.} and Aaron Brandes and Charles White and Brendan Keenan and Maria Cimpean and Phoebe Winn and Ioannis-Pavlos Panteliadis and Allison Robbins and Andlauer, {Till F. M.} and Onigiusz Zarzycki and Benedicte Dubois and An Goris and Sondergaard, {Helle Bach} and Finn Sellebjerg and Sorensen, {Per Soelberg} and Henrik Ullum and Thorner, {Lise Wegner} and Janna Saarela and Isabelle Cournu-Rebeix and Vincent Damotte and Bertrand Fontaine and Lena Guillot-Noel and Mark Lathrop and Sandra Vukusic and Achim Berthele and Viola Pongratz and Viola Pongratz and Christiane Gasperi and Christiane Graetz and Verena Grummel and Bernhard Hemmer and Muni Hoshi and Benjamin Knier and Thomas Korn and Lill, {Christina M.} and Felix Luessi and Mark Muehlau and Frauke Zipp and Efthimios Dardiotis and Cristina Agliardi and Antonio Amoroso and Nadia Barizzone and Benedetti, {Maria D.} and Luisa Bernardinelli and Paola Cavalla and Ferdinando Clarelli and Giancarlo Comi and Daniele Cusi and Federica Esposito and Laura Ferre and Daniela Galimberti and Clara Guaschino and Leone, {Maurizio A.} and Vittorio Martinelli and Lucia Moiola and Marco Salvetti and Melissa Sorosina and Domizia Vecchio and Andrea Zauli and Silvia Santoro and Nicasio Mancini and Miriam Zuccala and Julia Mescheriakova and {van Duijn}, Cornelia and Bos, {Steffan D.} and Celius, {Elisabeth G.} and Anne Spurkland and Manuel Comabella and Xavier Montalban and Lars Alfredsson and Bomfim, {Izaura L.} and David Gomez-Cabrero and Jan Hillert and Maja Jagodic and Magdalena Linden and Fredrik Piehl and Ilijas Jelcic and Roland Martin and Mirela Sospedra and Amie Baker and Maria Ban and Clive Hawkins and Pirro Hysi and Seema Kalra and Fredrik Karpe and Jyoti Khadake and Genevieve Lachance and Paul Molyneux and Matthew Neville and John Thorpe and Elizabeth Bradshaw and Caillier, {Stacy J.} and Peter Calabresi and Cree, {Bruce A. C.} and Anne Cross and Mary Davis and {de Bakker}, {Paul W. I.} and Silvia Delgado and Marieme Dembele and Keith Edwards and Kate Fitzgerald and Frohlich, {Irene Y.} and Pierre-Antoine Gourraud and Haines, {Jonathan L.} and Hakon Hakonarson and Dorlan Kimbrough and Noriko Isobe and Ioanna Konidari and Ellen Lathi and Lee, {Michelle H.} and Taibo Li and David An and Andrew Zimmer and Lohith Madireddy and Manrique, {Clara P.} and Mitja Mitrovic and Marta Olah and Ellis Patrick and Pericak-Vance, {Margaret A.} and Laura Piccio and Cathy Schaefer and Howard Weiner and Kasper Lage and Scott, {Rodney J.} and Jeannette Lechner-Scott and Rod Leal and Pablo Moscato and Booth, {David R.} and Graeme Stewart and Stephen Vucic and Grant Pame and Michael BamettO and Deborah Mason and Lyn GriffithS and Simon Broadley and Lotti Tajouri and Alan Baxter and Mark Slee and Taylor, {Bruce V.} and Jac Charlesworth and Kilpatrick, {Trevor J.} and Justin Rubio and Vilija Jokubaitis and James Wiley and Helmut Butzkueven and Stephen Leslie and Allan Motyer and Jim Stankovich and Carroll, {William M.} and Kermode, {Allan G.} and Marzena Edrin and Murray Barclay and Laurent Peyrin-Biroulet and Mathias Chamaillard and Jean-Frederick Colombe and Mario Cottone and Anthony Croft and Renata D'Inca and Jonas Halfvarson and Katherine Hanigan and Paul Henderson and Jean-Pierre Hugot and Amir Karban and Kennedy, {Nicholas A.} and Khan, {Mohammed Azam} and Marc Lemann and Arie Levine and Dunecan Massey and Monica Milla and Motoey, {Grant W.} and Ng, {Sok Meng Evelyn} and Joannis Oikonomnou and Harald Peeters and Proctor, {Deborah D.} and Jean-Francois Rahier and Rebecca Roberts and Paul Rutgeerts and Frank Seibold and Laura Stronati and Taylor, {Kirstin M.} and Leif Torkvist and Kullak Ublick and {Van Limbergen}, Johan and {Van Gossum}, Andre and Vatn, {Morten H.} and Hu Zhang and Wei Zhang and Peter Donnelly and Ines Barroso and Blackwe, {Jenefer M.} and Elvira Bramon and Brown, {Matthew A.} and Casas, {Juan P.} and Aiden Corvin and Panos Deloukas and Audrey Duncanson and Janusz Jankowski and Markus, {Hugh S.} and Mathew, {Christopher G.} and Palmer, {Colin N. A.} and Robert Plomin and Anna Rautanen and Stephen Sawcer and Trembath, {Richard C.} and Viswanathan, {Ananth C.} and Wood, {Nicholas W.} and Spencer, {Chris C. A.} and Gavin Band and Celine Bellenguez and Colin Freeman and Garrett Hellenthal and Eleni Giannoulatou and Matti Pirinen and Richard Pearson and Amy Strange and Zhan Sul and Vukcevic, {Damj An} and Peter Donnelly and Cordelia Langford and Hunt, {Sarah E.} and Sarah Edkins and Rhian Gwilliam and Hannah Blackburn and Bumpstead, {Suzannah J.} and Serge Dronov and Matthew Gillman and Emma Gray and Naomi Hammond and Alagurevathi Jayakumar and McCann, {Owen T.} and Jennifer Liddle and Potter, {Simon C.} and Radhi Ravindrarajah and Michelle Ricketts and Matthew Waller and Paul Weston and Brown, {Matthew A.} and Graeme Stewart",

year = "2019",

month = sep,

day = "27",

doi = "10.1126/science.aav7188",

language = "English",

volume = "365",

pages = "1417--+",

journal = "Science",

issn = "0036-8075",

publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

number = "6460",

}

Int Multiple Sclerosis Genetics Co, Int Multiple Sclerosis Genetics Co, ANZgene, IIBDGC, Australia New Zealand IBDGC, Belgium Genetic Consortiumt, Initiative Crohn Colitis, NIDDK IBDGCJ, United Kingdom IBDGC, Wellcome Trust Case Control Conso & WTCCC2 2019, 'Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility', Science, vol. 365, no. 6460, eaav7188, pp. 1417-+. https://doi.org/10.1126/science.aav7188

TY - JOUR

T1 - Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

AU - Int Multiple Sclerosis Genetics Co

AU - ANZgene

AU - IIBDGC

AU - Australia New Zealand IBDGC

AU - Belgium Genetic Consortiumt

AU - Initiative Crohn Colitis

AU - NIDDK IBDGCJ

AU - United Kingdom IBDGC

AU - Wellcome Trust Case Control Conso

AU - WTCCC2

AU - Patsopoulos, Nikolas A.

AU - Baranzini, Sergio E.

AU - Santaniello, Adams

AU - Shoostari, Parisa

AU - Cotsapas, Chris

AU - Wong, Garrett

AU - Beecham, Ashley H.

AU - James, Tojo

AU - Replogle, Joseph

AU - Vlachos, Ioannis S.

AU - McCabe, Cristin

AU - Pers, Tune H.

AU - Brandes, Aaron

AU - White, Charles

AU - Keenan, Brendan

AU - Cimpean, Maria

AU - Winn, Phoebe

AU - Panteliadis, Ioannis-Pavlos

AU - Robbins, Allison

AU - Andlauer, Till F. M.

AU - Zarzycki, Onigiusz

AU - Dubois, Benedicte

AU - Goris, An

AU - Sondergaard, Helle Bach

AU - Sellebjerg, Finn

AU - Sorensen, Per Soelberg

AU - Ullum, Henrik

AU - Thorner, Lise Wegner

AU - Saarela, Janna

AU - Cournu-Rebeix, Isabelle

AU - Damotte, Vincent

AU - Fontaine, Bertrand

AU - Guillot-Noel, Lena

AU - Lathrop, Mark

AU - Vukusic, Sandra

AU - Berthele, Achim

AU - Pongratz, Viola

AU - Gasperi, Christiane

AU - Graetz, Christiane

AU - Grummel, Verena

AU - Hemmer, Bernhard

AU - Hoshi, Muni

AU - Knier, Benjamin

AU - Korn, Thomas

AU - Lill, Christina M.

AU - Luessi, Felix

AU - Muehlau, Mark

AU - Zipp, Frauke

AU - Dardiotis, Efthimios

AU - Agliardi, Cristina

AU - Amoroso, Antonio

AU - Barizzone, Nadia

AU - Benedetti, Maria D.

AU - Bernardinelli, Luisa

AU - Cavalla, Paola

AU - Clarelli, Ferdinando

AU - Comi, Giancarlo

AU - Cusi, Daniele

AU - Esposito, Federica

AU - Ferre, Laura

AU - Galimberti, Daniela

AU - Guaschino, Clara

AU - Leone, Maurizio A.

AU - Martinelli, Vittorio

AU - Moiola, Lucia

AU - Salvetti, Marco

AU - Sorosina, Melissa

AU - Vecchio, Domizia

AU - Zauli, Andrea

AU - Santoro, Silvia

AU - Mancini, Nicasio

AU - Zuccala, Miriam

AU - Mescheriakova, Julia

AU - van Duijn, Cornelia

AU - Bos, Steffan D.

AU - Celius, Elisabeth G.

AU - Spurkland, Anne

AU - Comabella, Manuel

AU - Montalban, Xavier

AU - Alfredsson, Lars

AU - Bomfim, Izaura L.

AU - Gomez-Cabrero, David

AU - Hillert, Jan

AU - Jagodic, Maja

AU - Linden, Magdalena

AU - Piehl, Fredrik

AU - Jelcic, Ilijas

AU - Martin, Roland

AU - Sospedra, Mirela

AU - Baker, Amie

AU - Ban, Maria

AU - Hawkins, Clive

AU - Hysi, Pirro

AU - Kalra, Seema

AU - Karpe, Fredrik

AU - Khadake, Jyoti

AU - Lachance, Genevieve

AU - Molyneux, Paul

AU - Neville, Matthew

AU - Thorpe, John

AU - Bradshaw, Elizabeth

AU - Caillier, Stacy J.

AU - Calabresi, Peter

AU - Cree, Bruce A. C.

AU - Cross, Anne

AU - Davis, Mary

AU - de Bakker, Paul W. I.

AU - Delgado, Silvia

AU - Dembele, Marieme

AU - Edwards, Keith

AU - Fitzgerald, Kate

AU - Frohlich, Irene Y.

AU - Gourraud, Pierre-Antoine

AU - Haines, Jonathan L.

AU - Hakonarson, Hakon

AU - Kimbrough, Dorlan

AU - Isobe, Noriko

AU - Konidari, Ioanna

AU - Lathi, Ellen

AU - Lee, Michelle H.

AU - Li, Taibo

AU - An, David

AU - Zimmer, Andrew

AU - Madireddy, Lohith

AU - Manrique, Clara P.

AU - Mitrovic, Mitja

AU - Olah, Marta

AU - Patrick, Ellis

AU - Pericak-Vance, Margaret A.

AU - Piccio, Laura

AU - Schaefer, Cathy

AU - Weiner, Howard

AU - Lage, Kasper

AU - Scott, Rodney J.

AU - Lechner-Scott, Jeannette

AU - Leal, Rod

AU - Moscato, Pablo

AU - Booth, David R.

AU - Stewart, Graeme

AU - Vucic, Stephen

AU - Pame, Grant

AU - BamettO, Michael

AU - Mason, Deborah

AU - GriffithS, Lyn

AU - Broadley, Simon

AU - Tajouri, Lotti

AU - Baxter, Alan

AU - Slee, Mark

AU - Taylor, Bruce V.

AU - Charlesworth, Jac

AU - Kilpatrick, Trevor J.

AU - Rubio, Justin

AU - Jokubaitis, Vilija

AU - Wiley, James

AU - Butzkueven, Helmut

AU - Leslie, Stephen

AU - Motyer, Allan

AU - Stankovich, Jim

AU - Carroll, William M.

AU - Kermode, Allan G.

AU - Edrin, Marzena

AU - Barclay, Murray

AU - Peyrin-Biroulet, Laurent

AU - Chamaillard, Mathias

AU - Colombe, Jean-Frederick

AU - Cottone, Mario

AU - Croft, Anthony

AU - D'Inca, Renata

AU - Halfvarson, Jonas

AU - Hanigan, Katherine

AU - Henderson, Paul

AU - Hugot, Jean-Pierre

AU - Karban, Amir

AU - Kennedy, Nicholas A.

AU - Khan, Mohammed Azam

AU - Lemann, Marc

AU - Levine, Arie

AU - Massey, Dunecan

AU - Milla, Monica

AU - Motoey, Grant W.

AU - Ng, Sok Meng Evelyn

AU - Oikonomnou, Joannis

AU - Peeters, Harald

AU - Proctor, Deborah D.

AU - Rahier, Jean-Francois

AU - Roberts, Rebecca

AU - Rutgeerts, Paul

AU - Seibold, Frank

AU - Stronati, Laura

AU - Taylor, Kirstin M.

AU - Torkvist, Leif

AU - Ublick, Kullak

AU - Van Limbergen, Johan

AU - Van Gossum, Andre

AU - Vatn, Morten H.

AU - Zhang, Hu

AU - Zhang, Wei

AU - Donnelly, Peter

AU - Barroso, Ines

AU - Blackwe, Jenefer M.

AU - Bramon, Elvira

AU - Brown, Matthew A.

AU - Casas, Juan P.

AU - Corvin, Aiden

AU - Deloukas, Panos

AU - Duncanson, Audrey

AU - Jankowski, Janusz

AU - Markus, Hugh S.

AU - Mathew, Christopher G.

AU - Palmer, Colin N. A.

AU - Plomin, Robert

AU - Rautanen, Anna

AU - Sawcer, Stephen

AU - Trembath, Richard C.

AU - Viswanathan, Ananth C.

AU - Wood, Nicholas W.

AU - Spencer, Chris C. A.

AU - Band, Gavin

AU - Bellenguez, Celine

AU - Freeman, Colin

AU - Hellenthal, Garrett

AU - Giannoulatou, Eleni

AU - Pirinen, Matti

AU - Pearson, Richard

AU - Strange, Amy

AU - Sul, Zhan

AU - Vukcevic, Damj An

AU - Donnelly, Peter

AU - Langford, Cordelia

AU - Hunt, Sarah E.

AU - Edkins, Sarah

AU - Gwilliam, Rhian

AU - Blackburn, Hannah

AU - Bumpstead, Suzannah J.

AU - Dronov, Serge

AU - Gillman, Matthew

AU - Gray, Emma

AU - Hammond, Naomi

AU - Jayakumar, Alagurevathi

AU - McCann, Owen T.

AU - Liddle, Jennifer

AU - Potter, Simon C.

AU - Ravindrarajah, Radhi

AU - Ricketts, Michelle

AU - Waller, Matthew

AU - Weston, Paul

AU - Brown, Matthew A.

AU - Stewart, Graeme

PY - 2019/9/27

Y1 - 2019/9/27

KW - GENE-EXPRESSION

KW - DIAGNOSTIC-CRITERIA

KW - COMPLEX TRAITS

KW - RISK ALLELES

KW - ASSOCIATION

KW - AUTOIMMUNE

KW - HERITABILITY

KW - ARCHITECTURE

KW - METAANALYSIS

KW - MECHANISMS

U2 - 10.1126/science.aav7188

DO - 10.1126/science.aav7188

M3 - Article

C2 - 31604244

SN - 0036-8075

VL - 365

SP - 1417-+

JO - Science

JF - Science

IS - 6460

M1 - eaav7188

ER -