Multiple Risk Factors Induce NAFLD and Type 3/Type 2 diabetes with Links to various Chronic Diseases

In the year 2015 it is now estimated that 30% of the Western World will now progress to non alcoholic fatty liver disease (NAFLD) and by the year 2050 if NAFLD remains untreated in the Western world the prevalence of the disease may rise to 40% of the global population. Type 3 diabetes and circadian rhythm disturbances may be involved in the induction of NAFLD that may promote insulin resistance and various chronic diseases such as cardiovascular disease, pancreatic disease, kidney disease and neurodegenerative disease. Multiple risk factors that induce Type 3 diabetes and NAFLD include stress, magnesium deficiency, bacterial lipopolysaccharide contamination, drug induced toxicity, xenobiotic levels, unhealthy diet/lifestyle factors and defective thermoregulation. Early diagnosis of Type 3 diabetes by multiple assessment techniques such as proteomics, genomics and lipidomics may allow reversal or stabilization of NAFLD that may progress slowly from simple non-alcoholic liver steatosis. Early nutritional interventions with thermoregulation are esssential to maintain the heat shock gene Sirtuin 1 that is involved with the reversal of premature brain disease in Type 3 diabetes. Multiple risk factors are involved in the regulation of Sirtuin 1 with connections to the rapid metabolism of heat shock proteins and amyloid beta that determine the severity of insulin resistance and NAFLD in Type 3/Type 2 individuals in the Western World.