Multicarbazole scaffolds for selective G-quadruplex binding

Arnold Ou, Aurore Guédin , Brian Skelton, Samir Amrane, Cameron Evans, Marck Norret, Killugudi Swaminatha Iyer, Jean-Louis Mergny, Nicole Smith

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Herein we report a new class of G-quadruplex stablising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess Duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.
Original languageEnglish
Pages (from-to)9647-9650
JournalChemComm
Volume54
Issue number69
DOIs
Publication statusPublished - 2018

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