Multicarbazole scaffolds for selective G-quadruplex binding

Arnold Ou; Aurore  Guédin; Brian Skelton; Samir Amrane; Cameron Evans; Marck Norret; Killugudi Swaminatha Iyer; Jean-Louis Mergny; Nicole Smith

doi:10.1039/C8CC03945C

Multicarbazole scaffolds for selective G-quadruplex binding

Arnold Ou, Aurore Guédin , Brian Skelton, Samir Amrane, Cameron Evans, Marck Norret, Killugudi Swaminatha Iyer, Jean-Louis Mergny, Nicole Smith

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Herein we report a new class of G-quadruplex stablising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess Duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

Original language	English
Pages (from-to)	9647-9650
Number of pages	4
Journal	ChemComm
Volume	54
Issue number	69
DOIs	https://doi.org/10.1039/C8CC03945C
Publication status	Published - 2018

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title = "Multicarbazole scaffolds for selective G-quadruplex binding",

abstract = "Herein we report a new class of G-quadruplex stablising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess Duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.",

author = "Arnold Ou and Aurore Gu{\'e}din and Brian Skelton and Samir Amrane and Cameron Evans and Marck Norret and {Swaminatha Iyer}, Killugudi and Jean-Louis Mergny and Nicole Smith",

year = "2018",

doi = "10.1039/C8CC03945C",

language = "English",

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T1 - Multicarbazole scaffolds for selective G-quadruplex binding

AU - Ou, Arnold

AU - Guédin , Aurore

AU - Skelton, Brian

AU - Amrane, Samir

AU - Evans, Cameron

AU - Norret, Marck

AU - Swaminatha Iyer, Killugudi

AU - Mergny, Jean-Louis

AU - Smith, Nicole

PY - 2018

Y1 - 2018

N2 - Herein we report a new class of G-quadruplex stablising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess Duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

AB - Herein we report a new class of G-quadruplex stablising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess Duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

U2 - 10.1039/C8CC03945C

DO - 10.1039/C8CC03945C

M3 - Article

SN - 1359-7345

VL - 54

SP - 9647

EP - 9650

JO - ChemComm

JF - ChemComm

IS - 69

ER -

Multicarbazole scaffolds for selective G-quadruplex binding

Abstract

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