Multicarbazole scaffolds for selective G-quadruplex binding

Arnold Ou, Aurore Guédin , Brian Skelton, Samir Amrane, Cameron Evans, Marck Norret, Killugudi Swaminatha Iyer, Jean-Louis Mergny, Nicole Smith

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Herein we report a new class of G-quadruplex stablising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess Duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.
Original languageEnglish
Pages (from-to)9647-9650
JournalChemComm
Volume54
Issue number69
DOIs
Publication statusPublished - 2018

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Scaffolds
DNA
Ligands
Chain length
pyrrolidine
piperidine

Cite this

Ou, Arnold ; Guédin , Aurore ; Skelton, Brian ; Amrane, Samir ; Evans, Cameron ; Norret, Marck ; Swaminatha Iyer, Killugudi ; Mergny, Jean-Louis ; Smith, Nicole. / Multicarbazole scaffolds for selective G-quadruplex binding. In: ChemComm. 2018 ; Vol. 54, No. 69. pp. 9647-9650.
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Multicarbazole scaffolds for selective G-quadruplex binding. / Ou, Arnold; Guédin , Aurore ; Skelton, Brian; Amrane, Samir; Evans, Cameron; Norret, Marck; Swaminatha Iyer, Killugudi; Mergny, Jean-Louis; Smith, Nicole.

In: ChemComm, Vol. 54, No. 69, 2018, p. 9647-9650.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Multicarbazole scaffolds for selective G-quadruplex binding

AU - Ou, Arnold

AU - Guédin , Aurore

AU - Skelton, Brian

AU - Amrane, Samir

AU - Evans, Cameron

AU - Norret, Marck

AU - Swaminatha Iyer, Killugudi

AU - Mergny, Jean-Louis

AU - Smith, Nicole

PY - 2018

Y1 - 2018

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AB - Herein we report a new class of G-quadruplex stablising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess Duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

U2 - 10.1039/C8CC03945C

DO - 10.1039/C8CC03945C

M3 - Article

VL - 54

SP - 9647

EP - 9650

JO - Chemical Communications, 2000

JF - Chemical Communications, 2000

SN - 1359-7345

IS - 69

ER -