Herein we report a new class of G-quadruplex stablising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess Duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.
|Number of pages||4|
|Publication status||Published - 2018|