Multi-route antifungal administration in the management of urinary Candida glabrata bezoar

Pravin Viswambaram; Jeanie Misko; Matthew Rawlins; Sarah Clark; John Dyer; Dickon Hayne

doi:10.1016/j.eucr.2020.101275

Multi-route antifungal administration in the management of urinary Candida glabrata bezoar

Pravin Viswambaram
, Jeanie Misko
, Matthew Rawlins
, Sarah Clark
, John Dyer
, Dickon Hayne

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. Candida glabrata cultured from urine was resistant to fluconazole. Amphotericin B was instilled into the renal pelvis via the nephrostomy tube while intravenous liposomal amphotericin was administered daily along with oral flucytosine. This multi-modal antifungal administration was continued for 14 days. Clinical and biochemical improvement was achieved and repeat imaging showed complete resolution of the filling defects and hydronephrosis.

Original language	English
Article number	101275
Journal	Urology Case Reports
Volume	33
DOIs	https://doi.org/10.1016/j.eucr.2020.101275
Publication status	Published - Nov 2020

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10.1016/j.eucr.2020.101275

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title = "Multi-route antifungal administration in the management of urinary Candida glabrata bezoar",

abstract = "A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. Candida glabrata cultured from urine was resistant to fluconazole. Amphotericin B was instilled into the renal pelvis via the nephrostomy tube while intravenous liposomal amphotericin was administered daily along with oral flucytosine. This multi-modal antifungal administration was continued for 14 days. Clinical and biochemical improvement was achieved and repeat imaging showed complete resolution of the filling defects and hydronephrosis.",

keywords = "Amphotericin B, Hydronephrosis, Percutaneous nephrostomy tube, Urinary fungal bezoar",

author = "Pravin Viswambaram and Jeanie Misko and Matthew Rawlins and Sarah Clark and John Dyer and Dickon Hayne",

year = "2020",

month = nov,

doi = "10.1016/j.eucr.2020.101275",

language = "English",

volume = "33",

journal = "Urology Case Reports",

issn = "2214-4420",

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T1 - Multi-route antifungal administration in the management of urinary Candida glabrata bezoar

AU - Viswambaram, Pravin

AU - Misko, Jeanie

AU - Rawlins, Matthew

AU - Clark, Sarah

AU - Dyer, John

AU - Hayne, Dickon

PY - 2020/11

Y1 - 2020/11

N2 - A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. Candida glabrata cultured from urine was resistant to fluconazole. Amphotericin B was instilled into the renal pelvis via the nephrostomy tube while intravenous liposomal amphotericin was administered daily along with oral flucytosine. This multi-modal antifungal administration was continued for 14 days. Clinical and biochemical improvement was achieved and repeat imaging showed complete resolution of the filling defects and hydronephrosis.

AB - A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. Candida glabrata cultured from urine was resistant to fluconazole. Amphotericin B was instilled into the renal pelvis via the nephrostomy tube while intravenous liposomal amphotericin was administered daily along with oral flucytosine. This multi-modal antifungal administration was continued for 14 days. Clinical and biochemical improvement was achieved and repeat imaging showed complete resolution of the filling defects and hydronephrosis.

KW - Amphotericin B

KW - Hydronephrosis

KW - Percutaneous nephrostomy tube

KW - Urinary fungal bezoar

UR - https://www.scopus.com/pages/publications/85085289134

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DO - 10.1016/j.eucr.2020.101275

M3 - Article

C2 - 32489899

AN - SCOPUS:85085289134

SN - 2214-4420

VL - 33

JO - Urology Case Reports

JF - Urology Case Reports

M1 - 101275

ER -

Multi-route antifungal administration in the management of urinary Candida glabrata bezoar

Abstract

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