Multi-model approach shows novel and diverse effects of low-intensity repetitive transcranial magnetic stimulation on brain cells and behaviour

Jessica Moretti

doi:10.26182/9r52-p852

Multi-model approach shows novel and diverse effects of low-intensity repetitive transcranial magnetic stimulation on brain cells and behaviour

Jessica Moretti

Research output: Thesis › Doctoral Thesis

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique used to treat neurological disorders and modulate cognition. Although rTMS can induce various benefits, its mechanisms are not well understood. Recent research with animal models has used low intensity (LI-) rTMS to explore mechanisms, with evidence of cellular changes and limited behavioural effects. Therefore this thesis aims to expand LI-rTMS research to a wider scope, from subcellular to network levels. This thesis investigates LI-rTMS-induced changes in mitochondria, whole-brain neuronal activity and functional connectivity, and investigates behavioural effects, both in animal models and, for the first time, in humans.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Rodger, Jennifer, Supervisor Visser, Troy, Supervisor Harvey, Alan, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	11 Jun 2023
DOIs	https://doi.org/10.26182/9r52-p852
Publication status	Unpublished - 2023

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10.26182/9r52-p852

THESIS - DOCTOR OF PHILOSOPHY - MORETTI Jessica - 2023
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3 Article
1 Review article

Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated c-Fos expression
Moretti, J., Terstege, D. J., Poh, E. Z., Epp, J. R. & Rodger, J., Dec 2022, In: Scientific Reports. 12, 1, 20571.
Research output: Contribution to journal › Article › peer-review

Open Access
15 Citations (Scopus)
Offline Parietal Intermittent Theta Burst Stimulation or Alpha Frequency Transcranial Alternating Current Stimulation Has No Effect on Visuospatial or Temporal Attention
Moretti, J., Marinovic, W., Harvey, A. R., Rodger, J. & Visser, T. A. W., 14 Jun 2022, In: Frontiers in Neuroscience. 16, 903977.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Citations (Scopus)
Concurrent LI-rTMS induces changes in c-Fos expression but not behavior during a progressive ratio task with adult ephrin-A2A5^-/- mice
Moretti, J., Poh, E. Z., Bolland, S. J., Harvey, A. R., Albrecht, M. A. & Rodger, J., 26 Feb 2021, In: Behavioural Brain Research. 400, 113011.
Research output: Contribution to journal › Article › peer-review

Open Access
File
6 Citations (Scopus)

Cite this

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title = "Multi-model approach shows novel and diverse effects of low-intensity repetitive transcranial magnetic stimulation on brain cells and behaviour",

abstract = "Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique used to treat neurological disorders and modulate cognition. Although rTMS can induce various benefits, its mechanisms are not well understood. Recent research with animal models has used low intensity (LI-) rTMS to explore mechanisms, with evidence of cellular changes and limited behavioural effects. Therefore this thesis aims to expand LI-rTMS research to a wider scope, from subcellular to network levels. This thesis investigates LI-rTMS-induced changes in mitochondria, whole-brain neuronal activity and functional connectivity, and investigates behavioural effects, both in animal models and, for the first time, in humans.",

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year = "2023",

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AB - Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique used to treat neurological disorders and modulate cognition. Although rTMS can induce various benefits, its mechanisms are not well understood. Recent research with animal models has used low intensity (LI-) rTMS to explore mechanisms, with evidence of cellular changes and limited behavioural effects. Therefore this thesis aims to expand LI-rTMS research to a wider scope, from subcellular to network levels. This thesis investigates LI-rTMS-induced changes in mitochondria, whole-brain neuronal activity and functional connectivity, and investigates behavioural effects, both in animal models and, for the first time, in humans.

KW - repetitive transcranial magnetic stimulation

KW - non-invasive brain stimulation

KW - cognition

KW - cFos

KW - neuronal activity

KW - mitochondria

KW - ephrin

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DO - 10.26182/9r52-p852

M3 - Doctoral Thesis

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Multi-model approach shows novel and diverse effects of low-intensity repetitive transcranial magnetic stimulation on brain cells and behaviour

Abstract

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Research output

Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated c-Fos expression

Offline Parietal Intermittent Theta Burst Stimulation or Alpha Frequency Transcranial Alternating Current Stimulation Has No Effect on Visuospatial or Temporal Attention

Concurrent LI-rTMS induces changes in c-Fos expression but not behavior during a progressive ratio task with adult ephrin-A2A5-/- mice

Cite this

Concurrent LI-rTMS induces changes in c-Fos expression but not behavior during a progressive ratio task with adult ephrin-A2A5^-/- mice