Mouse models of age-related macular degeneration

Elizabeth Rakoczy; M. Yu; S. Nusinowitz; B. Chang; J.R. Heckenlively

doi:10.1016/j.exer.2005.10.012

Mouse models of age-related macular degeneration

Elizabeth Rakoczy, M. Yu, S. Nusinowitz, B. Chang, J.R. Heckenlively

Centre for Ophthalmology and Visual Science (affiliated with the Lions Eye Institute)

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Recent advances in genetic technologies have greatly accelerated our ability to find disease-related genes and to generate animal models. The availability of ocular tissues with known genetic diseases are greatly contributing to our understanding of retinal disease processes including age-related macular degeneration (AMD), and panretinal and cone degenerations. While the macula is a highly specialised area of the retina not present in many mammals, the use of animal models such as mouse strains will give basic physiology and visual processing genetics relevant to human AMD. This review aims to provide a framework for better understanding some of the existing animal models and the knowledge that has been derived from their evaluations. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	741-752
Journal	Experimental Eye Research
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/j.exer.2005.10.012
Publication status	Published - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.exer.2005.10.012

Cite this

@article{2f2db6f8b45b47a38094af956cf3087b,

title = "Mouse models of age-related macular degeneration",

abstract = "Recent advances in genetic technologies have greatly accelerated our ability to find disease-related genes and to generate animal models. The availability of ocular tissues with known genetic diseases are greatly contributing to our understanding of retinal disease processes including age-related macular degeneration (AMD), and panretinal and cone degenerations. While the macula is a highly specialised area of the retina not present in many mammals, the use of animal models such as mouse strains will give basic physiology and visual processing genetics relevant to human AMD. This review aims to provide a framework for better understanding some of the existing animal models and the knowledge that has been derived from their evaluations. (c) 2005 Elsevier Ltd. All rights reserved.",

author = "Elizabeth Rakoczy and M. Yu and S. Nusinowitz and B. Chang and J.R. Heckenlively",

year = "2006",

doi = "10.1016/j.exer.2005.10.012",

language = "English",

volume = "82",

pages = "741--752",

journal = "Experimental Eye Research",

issn = "0014-4835",

publisher = "Academic Press",

number = "5",

}

TY - JOUR

T1 - Mouse models of age-related macular degeneration

AU - Rakoczy, Elizabeth

AU - Yu, M.

AU - Nusinowitz, S.

AU - Chang, B.

AU - Heckenlively, J.R.

PY - 2006

Y1 - 2006

N2 - Recent advances in genetic technologies have greatly accelerated our ability to find disease-related genes and to generate animal models. The availability of ocular tissues with known genetic diseases are greatly contributing to our understanding of retinal disease processes including age-related macular degeneration (AMD), and panretinal and cone degenerations. While the macula is a highly specialised area of the retina not present in many mammals, the use of animal models such as mouse strains will give basic physiology and visual processing genetics relevant to human AMD. This review aims to provide a framework for better understanding some of the existing animal models and the knowledge that has been derived from their evaluations. (c) 2005 Elsevier Ltd. All rights reserved.

AB - Recent advances in genetic technologies have greatly accelerated our ability to find disease-related genes and to generate animal models. The availability of ocular tissues with known genetic diseases are greatly contributing to our understanding of retinal disease processes including age-related macular degeneration (AMD), and panretinal and cone degenerations. While the macula is a highly specialised area of the retina not present in many mammals, the use of animal models such as mouse strains will give basic physiology and visual processing genetics relevant to human AMD. This review aims to provide a framework for better understanding some of the existing animal models and the knowledge that has been derived from their evaluations. (c) 2005 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.exer.2005.10.012

DO - 10.1016/j.exer.2005.10.012

M3 - Article

C2 - 16325179

SN - 0014-4835

VL - 82

SP - 741

EP - 752

JO - Experimental Eye Research

JF - Experimental Eye Research

IS - 5

ER -

Mouse models of age-related macular degeneration

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this