Mouse models for muscular dystrophies: an overview

Maaike van Putten, Erin M. Lloyd, Jessica C. de Greef, Vered Raz, Raffaella Willmann, Miranda D. Grounds

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Muscular dystrophies (MDs) encompass a wide variety of inherited disorders that are characterized by loss of muscle tissue associated with a progressive reduction in muscle function. With a cure lacking for MDs, preclinical developments of therapeutic approaches depend on well-characterized animal models that recapitulate the specific pathology in patients. The mouse is the most widely and extensively used model for MDs, and it has played a key role in our understanding of the molecular mechanisms underlying MD pathogenesis. This has enabled the development of therapeutic strategies. Owing to advancements in genetic engineering, a wide variety of mouse models are available for the majority of MDs. Here, we summarize the characteristics of the most commonly used mouse models for a subset of highly studied MDs, collated into a table. Together with references to key publications describing these models, this brief but detailed overview would be useful for those interested in, or working with, mouse models of MD.

Original languageEnglish
JournalDisease models & mechanisms
Volume13
Issue number2
DOIs
Publication statusPublished - 21 Feb 2020

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    van Putten, M., Lloyd, E. M., de Greef, J. C., Raz, V., Willmann, R., & Grounds, M. D. (2020). Mouse models for muscular dystrophies: an overview. Disease models & mechanisms, 13(2). https://doi.org/10.1242/dmm.043562