Motor cortex reorganisation in Parkinson's disease

Gary Thickbroom, Michelle Byrnes, S. Walters, R. Stell, Francis Mastaglia

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18 Citations (Scopus)


Transcranial magnetic stimulation mapping of the motor cortical projection to the hand was performed in a group of patients with Parkinson's disease (PD) of variable duration to determine whether there is evidence of cortical reorganisation. Map shifts were found in the majority of PD cases (12/15), in untreated early cases as well as treated cases of longer duration, and there was a correlation between inter-side difference in the severity of PD symptoms (Unified Parkinson's Disease Rating Scale) and interhemispheric map displacement (r = 0.60; P = 0.018). These findings indicate that there is reorganisation of the corticomotor representation of the hand in PD, even at a relatively early stage of the disease, and suggest a dynamic process of reorganisation in the motor cortex due to an increase in the pallidal inhibitory inputs to the thalamo-cortical projections. (c) 2006 Published by Elsevier Ltd.
Original languageEnglish
Pages (from-to)639-642
JournalJournal of Clinical Neuroscience
Issue number6
Publication statusPublished - 2006


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