More trials for the unhappy hypothyroid patient on thyroxine: a clinician's perspective

Timothy A. Welborn

doi:10.1016/j.tem.2022.04.010

More trials for the unhappy hypothyroid patient on thyroxine: a clinician's perspective

Timothy A. Welborn

Internal Medicine

Research output: Contribution to journal › Short survey › peer-review

Abstract

Further clinical trials are proposed for the 5–15% of hypothyroid patients who are dissatisfied with thyroxine (T4) monotherapy. Those responding to combination therapy [T4 plus triiodothyronine (T3)] will show suggestive biochemistry and abnormal reflexes. Those with Hashimoto's disease and very high anti-thyroid peroxidase (anti-TPO) thyroid antibody levels may benefit from total thyroidectomy. The remainder have negative clinical and laboratory findings and require supportive management.

Original language	English
Pages (from-to)	536-538
Number of pages	3
Journal	Trends in Endocrinology and Metabolism
Volume	33
Issue number	8
Early online date	2022
DOIs	https://doi.org/10.1016/j.tem.2022.04.010
Publication status	Published - Aug 2022

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10.1016/j.tem.2022.04.010

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abstract = "Further clinical trials are proposed for the 5–15% of hypothyroid patients who are dissatisfied with thyroxine (T4) monotherapy. Those responding to combination therapy [T4 plus triiodothyronine (T3)] will show suggestive biochemistry and abnormal reflexes. Those with Hashimoto's disease and very high anti-thyroid peroxidase (anti-TPO) thyroid antibody levels may benefit from total thyroidectomy. The remainder have negative clinical and laboratory findings and require supportive management.",

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AB - Further clinical trials are proposed for the 5–15% of hypothyroid patients who are dissatisfied with thyroxine (T4) monotherapy. Those responding to combination therapy [T4 plus triiodothyronine (T3)] will show suggestive biochemistry and abnormal reflexes. Those with Hashimoto's disease and very high anti-thyroid peroxidase (anti-TPO) thyroid antibody levels may benefit from total thyroidectomy. The remainder have negative clinical and laboratory findings and require supportive management.

KW - abnormal reflexes

KW - combination therapy

KW - Hashimoto's disease

KW - hypothyroidism

KW - thyroidectomy

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JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 8

ER -

More trials for the unhappy hypothyroid patient on thyroxine: a clinician's perspective

Abstract

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