Morbidity and mortality in patient with an opioid use disorder and their children following treatment with a sustained release naltrexone preparation

Erin Amanda Kelty

doi:10.4225/23/59533e0d46526

Morbidity and mortality in patient with an opioid use disorder and their children following treatment with a sustained release naltrexone preparation

Erin Amanda Kelty

Research output: Thesis › Doctoral Thesis

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Abstract

The aim of this thesis was to examine the safety of implant naltrexone in the treatment of non-pregnant and pregnant opioid dependent patients and their children.

State and national health data were used to examine the health of patients treated with naltrexone, methadone and buprenorphine and the health of children who had been exposed to one of these opioid pharmacotherapies in utero.

Rates of morbidity and mortality were largely comparable between implant naltrexone, methadone and buprenorphine treated patients. Rates of birth were significantly elevated in women treated with naltrexone, however maternal and child health outcomes were positive.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Hulse, Gary, Supervisor Bennett, Kellie, Supervisor
Award date	13 Jun 2017
DOIs	https://doi.org/10.4225/23/59533e0d46526
Publication status	Unpublished - 2017

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10.4225/23/59533e0d46526

THESIS - DOCTOR OF PHILOSOPHY - KELTY Erin Amanda - 2017
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title = "Morbidity and mortality in patient with an opioid use disorder and their children following treatment with a sustained release naltrexone preparation",

abstract = "The aim of this thesis was to examine the safety of implant naltrexone in the treatment of non-pregnant and pregnant opioid dependent patients and their children.State and national health data were used to examine the health of patients treated with naltrexone, methadone and buprenorphine and the health of children who had been exposed to one of these opioid pharmacotherapies in utero.Rates of morbidity and mortality were largely comparable between implant naltrexone, methadone and buprenorphine treated patients. Rates of birth were significantly elevated in women treated with naltrexone, however maternal and child health outcomes were positive.",

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AU - Kelty, Erin Amanda

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N2 - The aim of this thesis was to examine the safety of implant naltrexone in the treatment of non-pregnant and pregnant opioid dependent patients and their children.State and national health data were used to examine the health of patients treated with naltrexone, methadone and buprenorphine and the health of children who had been exposed to one of these opioid pharmacotherapies in utero.Rates of morbidity and mortality were largely comparable between implant naltrexone, methadone and buprenorphine treated patients. Rates of birth were significantly elevated in women treated with naltrexone, however maternal and child health outcomes were positive.

AB - The aim of this thesis was to examine the safety of implant naltrexone in the treatment of non-pregnant and pregnant opioid dependent patients and their children.State and national health data were used to examine the health of patients treated with naltrexone, methadone and buprenorphine and the health of children who had been exposed to one of these opioid pharmacotherapies in utero.Rates of morbidity and mortality were largely comparable between implant naltrexone, methadone and buprenorphine treated patients. Rates of birth were significantly elevated in women treated with naltrexone, however maternal and child health outcomes were positive.

KW - Naltrexone

KW - Methadone

KW - Buprenorphine

KW - Mortality

KW - Morbiditiy

KW - Pregnancy

KW - Neonatal health

U2 - 10.4225/23/59533e0d46526

DO - 10.4225/23/59533e0d46526

M3 - Doctoral Thesis

ER -

Morbidity and mortality in patient with an opioid use disorder and their children following treatment with a sustained release naltrexone preparation

Abstract

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