Mononuclear Cell Factors that Inhibit Fibroblast Collagen Synthesis: I. In Vitro Conditions Determining Their Production and Expression

P. H. HART, L. W. POWELL, W. G.E. COOKSLEY, J. W. HALLIDAY

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Peripheral blood mononuclear cells (PBMC) incubated either with phytohaemagglutinin‐P (PHA) under serum‐free conditions or with tuberculin purified protein derivative in the presence of 5% human blood group AB serum released into the culture medium factors that decreased collagen synthesis by dermal fibroblasts. These factors were first detected after incubation of PBMC with PHA for 24 h and were produced by non‐adherent cells. The decrease in collagen synthesis was observed despite changes in conditions of fibroblast culture, the addition of a cross‐linking inhibitor, and the use of different fibroblast cell lines.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalScandinavian Journal of Immunology
Volume18
Issue number1
DOIs
Publication statusPublished - 1 Jan 1983
Externally publishedYes

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