© 2014 Elsevier B.V. The Shuangqing Fe-Pb-Zn-Cu deposit is located in the Xiangride County of Qinghai Province, China, and is a typical example of skarn deposits in the East Kunlun Mountains. Skarnization and mineralization took place along the contact zone between Carboniferous carbonates and the concealed Triassic plagiogranite. LA-ICP-MS U-Pb dating of zircons from the plagiogranite has yielded ages of 227.2±1.0 and 226.54±0.97Ma, which are interpreted as the emplacement age of the plagiogranite. Molybdenites separated from ore-bearing quartz-veins yielded a Re-Os isochron age of 226.5±5.1Ma. These age data confirm that both intrusion and related skarn mineralization initiated at ~227Ma. Re contents of molybdenite, zircon εHf(t) and 176Hf/177Hf values fall into the ranges 3.31 to 6.58μg/g, -8.6 to -0.0, and 0.282403 to 0.28263850, respectively. The timing of the Shuangqing Fe-Pb-Zn-Cu mineralization coincided with a major change in the stress field in East Kunlun from transpression to extension, related to the partial melting of thickening crustal materials in a post-collisional tectonic setting.