Molecular mechanisms of muscular dystrophies: old and new players

K.E. Davies, Kristen Nowak

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

The study of the muscle cell in the muscular dystrophies (MDs) has shown that mutant proteins result in perturbations of many cellular components. MDs have been associated with mutations in structural proteins, signalling molecules and enzymes as well as mutations that result in aberrant processing of mRNA or alterations in post-translational modifications of proteins. These findings have not only revealed important insights for cell biologists, but have also provided unexpected and exciting new approaches for therapy.
Original languageEnglish
Pages (from-to)762-773
JournalNature Reviews Molecular Cell Biology
Volume7
Issue number10
DOIs
Publication statusPublished - 2006

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