Molecular mechanisms of adaptive evolution revealed by global selection for glyphosate resistance

Todd A. Gaines, Eric L. Patterson, Paul Neve

Research output: Contribution to journalReview articlepeer-review

70 Citations (Scopus)

Abstract

The human-directed, global selection for glyphosate resistance in weeds has revealed a fascinating diversity of evolved resistance mechanisms, including herbicide sequestration in the vacuole, a rapid cell death response, nucleotide polymorphisms in the herbicide target (5-enolpyruvylshikimate-3-phosphate synthase, EPSPS) and increased gene copy number of EPSPS. For this latter mechanism, two distinct molecular genetic mechanisms have been observed, a tandem duplication mechanism and a large extrachromosomal circular DNA (eccDNA) that is tethered to the chromosomes and passed to gametes at meiosis. These divergent mechanisms have a range of consequences for the spread, fitness, and inheritance of resistance traits, and, particularly in the case of the eccDNA, demonstrate how evolved herbicide resistance can generate new insights into plant adaptation to contemporary environmental stress.
Original languageEnglish
Pages (from-to)1770-1775
Number of pages6
JournalNew Phytologist
Volume223
Issue number4
DOIs
Publication statusPublished - Sept 2019
Externally publishedYes

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