TY - JOUR
T1 - Molecular mechanisms linking stress and insulin resistance
AU - Yaribeygi, Habib
AU - Maleki, Mina
AU - Butler, Alexandra E.
AU - Jamialahmadi, Tannaz
AU - Sahebkar, Amirhossein
PY - 2022/1/3
Y1 - 2022/1/3
N2 - To date, there is ample evidence to support the strong relationship between stress and insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an upstream event for insulin resistance as well. It is widely recognized that diabetes mellitus is more prevalent among people who have a stressful lifestyle; however, the underlying mechanisms are not well understood. In the current study, we surveyed the scientific literature for possible interactions between stress and insulin resistance and found that stress can impair glucose homeostasis, working through at least six molecular pathways.
AB - To date, there is ample evidence to support the strong relationship between stress and insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an upstream event for insulin resistance as well. It is widely recognized that diabetes mellitus is more prevalent among people who have a stressful lifestyle; however, the underlying mechanisms are not well understood. In the current study, we surveyed the scientific literature for possible interactions between stress and insulin resistance and found that stress can impair glucose homeostasis, working through at least six molecular pathways.
KW - Diabetes mellitus
KW - Immune system
KW - Insulin resistance
KW - Insulin signal transduction
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=85130724658&partnerID=8YFLogxK
U2 - 10.17179/excli2021-4382
DO - 10.17179/excli2021-4382
M3 - Article
C2 - 35368460
AN - SCOPUS:85130724658
SN - 1611-2156
VL - 21
SP - 317
EP - 334
JO - EXCLI Journal
JF - EXCLI Journal
ER -
