Molecular insight into invasive group A streptococcal disease

Jason N. Cole, Timothy C. Barnett, Victor Nizet, Mark J. Walker

Research output: Contribution to journalReview article

245 Citations (Scopus)

Abstract

Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important human pathogen that causes considerable morbidity and mortality worldwide. The GAS serotype M1T1 clone is the most frequently isolated serotype from life-threatening invasive (at a sterile site) infections, such as streptococcal toxic shock-like syndrome and necrotizing fasciitis. Here, we describe the virulence factors and newly discovered molecular events that mediate the in vivo changes from non-invasive GAS serotype M1T1 to the invasive phenotype, and review the invasive-disease trigger for non-M1 GAS. Understanding the molecular basis and mechanism of initiation for streptococcal invasive disease may expedite the discovery of novel therapeutic targets for the treatment and control of severe invasive GAS diseases.

Original languageEnglish
Pages (from-to)724-736
Number of pages13
JournalNature Reviews Microbiology
Volume9
Issue number10
DOIs
Publication statusPublished - 1 Oct 2011
Externally publishedYes

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