Molecular characterisation of murine and human malignant mesothelioma and the identification of neoantigens as potential targets for therapy using next generation sequencing

Sophie Sneddon

doi:10.4225/23/594a1139df0c6

Molecular characterisation of murine and human malignant mesothelioma and the identification of neoantigens as potential targets for therapy using next generation sequencing

Sophie Sneddon

Research output: Thesis › Doctoral Thesis

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Abstract

Malignant mesothelioma Is a fatal malignancy of the thoracic cavity caused by exposure to asbestos. There is an urgent need for innovative treatment strategies that harness the unique characteristics of each tumour and the complex tumour- immune Interaction. This thesis provides an In depth genomic characterisation of an asbestos induced wild-type murine model of mesothelioma and tumour cells from pleural effusions from 27 human patients. This thesis also demonstrates an immune response to a neoantigen produced by a mutation in a mesothelioma patient. Therefore, the mutations contained in mesothelioma tumour cells can be exploited to develop personalised immunotherapeutic treatment strategies.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Creaney, Jenette, Supervisor Robinson, Bruce, Supervisor
Award date	31 May 2017
DOIs	https://doi.org/10.4225/23/594a1139df0c6
Publication status	Unpublished - 2017

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10.4225/23/594a1139df0c6

THESIS - DOCTOR OF PHILOSOPHY - SNEDDON Sophie Ann - 2017
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Cite this

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title = "Molecular characterisation of murine and human malignant mesothelioma and the identification of neoantigens as potential targets for therapy using next generation sequencing",

abstract = "Malignant mesothelioma Is a fatal malignancy of the thoracic cavity caused by exposure to asbestos. There is an urgent need for innovative treatment strategies that harness the unique characteristics of each tumour and the complex tumour- immune Interaction. This thesis provides an In depth genomic characterisation of an asbestos induced wild-type murine model of mesothelioma and tumour cells from pleural effusions from 27 human patients. This thesis also demonstrates an immune response to a neoantigen produced by a mutation in a mesothelioma patient. Therefore, the mutations contained in mesothelioma tumour cells can be exploited to develop personalised immunotherapeutic treatment strategies.",

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school = "The University of Western Australia",

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AB - Malignant mesothelioma Is a fatal malignancy of the thoracic cavity caused by exposure to asbestos. There is an urgent need for innovative treatment strategies that harness the unique characteristics of each tumour and the complex tumour- immune Interaction. This thesis provides an In depth genomic characterisation of an asbestos induced wild-type murine model of mesothelioma and tumour cells from pleural effusions from 27 human patients. This thesis also demonstrates an immune response to a neoantigen produced by a mutation in a mesothelioma patient. Therefore, the mutations contained in mesothelioma tumour cells can be exploited to develop personalised immunotherapeutic treatment strategies.

KW - Mesothelioma

KW - Asbestos

KW - Mutational landscape

KW - Neoantigen

KW - Murine model

KW - Pleural effusion

KW - Bioinformatics

KW - Next generation sequencing

U2 - 10.4225/23/594a1139df0c6

DO - 10.4225/23/594a1139df0c6

M3 - Doctoral Thesis

ER -

Molecular characterisation of murine and human malignant mesothelioma and the identification of neoantigens as potential targets for therapy using next generation sequencing

Abstract

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