Malignant mesothelioma Is a fatal malignancy of the thoracic cavity caused by exposure to asbestos. There is an urgent need for innovative treatment strategies that harness the unique characteristics of each tumour and the complex tumour- immune Interaction. This thesis provides an In depth genomic characterisation of an asbestos induced wild-type murine model of mesothelioma and tumour cells from pleural effusions from 27 human patients. This thesis also demonstrates an immune response to a neoantigen produced by a mutation in a mesothelioma patient. Therefore, the mutations contained in mesothelioma tumour cells can be exploited to develop personalised immunotherapeutic treatment strategies.
|Qualification||Doctor of Philosophy|
|Award date||31 May 2017|
|Publication status||Unpublished - 2017|