Molecular biology and epidemiology of multi-resistant Klebsiella pneumoniae in Western Australia

Jarrad Michael Hall

    Research output: ThesisDoctoral Thesis

    984 Downloads (Pure)

    Abstract

    Antimicrobial resistance is a critical human health threat projected to claim 10 million lives a year by 2050, among which carbapenemase-producing (CPE) Klebsiella pneumoniae are a leading priority. Mitigation relies on rapid detection, based on its molecular biology and ecology . I studied the predominant molecular types of CPE in Sri Lanka (bla NDM and OXA 181 ST14 and ST147) and Western Australia (bla IMP-4 no major sequence type). International human movement has introduced CPE to WA. I developed a rapid assay that determines meropenem resistance shortly after antimicrobial exposure ,and went on to examine environmental determinants of carbapenem resistance.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Inglis, Tim, Supervisor
    • Beilharz, Manfred, Supervisor
    • Ingram, Paul, Supervisor
    Award date15 Mar 2017
    Publication statusUnpublished - 2016

    Embargo information

    • Embargoed from 23/03/17 to 23/05/17. Made publicly available on 24/05/17.

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