Abstract
Antimicrobial resistance is a critical human health threat projected to claim 10 million lives a year by 2050, among which carbapenemase-producing (CPE) Klebsiella pneumoniae are a leading priority. Mitigation relies on rapid detection, based on its molecular biology and ecology . I studied the predominant molecular types of CPE in Sri Lanka (bla NDM and OXA 181 ST14 and ST147) and Western Australia (bla IMP-4 no major sequence type). International human movement has introduced CPE to WA. I developed a rapid assay that determines meropenem resistance shortly after antimicrobial exposure ,and went on to examine environmental determinants of carbapenem resistance.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Supervisors/Advisors |
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Award date | 15 Mar 2017 |
Publication status | Unpublished - 2016 |
Embargo information
- Embargoed from 23/03/17 to 23/05/17. Made publicly available on 24/05/17.