Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition: A narrative review

Jane Tan, Kartik K. Iyer, Alexander D. Tang, Asif Jamil, Ralph N. Martins, Hamid R. Sohrabi, Michael A. Nitsche, Mark R. Hinder, Hakuei Fujiyama

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Response inhibition, the ability to withhold a dominant and prepotent response following a change in circumstance or sensory stimuli, declines with advancing age. While non-invasive brain stimulation (NiBS) has shown promise in alleviating some cognitive and motor functions in healthy older individuals, NiBS research focusing on response inhibition has mostly been conducted on younger adults. These extant studies have primarily focused on modulating the activity of distinct neural regions known to be critical for response inhibition, including the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA). However, given that changes in structural and functional connectivity have been associated with healthy aging, this review proposes that NiBS protocols aimed at modulating the functional connectivity between the rIFG and pre-SMA may be the most efficacious approach to investigate-and perhaps even alleviate-age-related deficits in inhibitory control.

Original languageEnglish
Pages (from-to)490-512
Number of pages23
JournalNeuroImage
Volume185
DOIs
Publication statusPublished - 15 Jan 2019

Cite this

Tan, Jane ; Iyer, Kartik K. ; Tang, Alexander D. ; Jamil, Asif ; Martins, Ralph N. ; Sohrabi, Hamid R. ; Nitsche, Michael A. ; Hinder, Mark R. ; Fujiyama, Hakuei. / Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition : A narrative review. In: NeuroImage. 2019 ; Vol. 185. pp. 490-512.
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abstract = "Response inhibition, the ability to withhold a dominant and prepotent response following a change in circumstance or sensory stimuli, declines with advancing age. While non-invasive brain stimulation (NiBS) has shown promise in alleviating some cognitive and motor functions in healthy older individuals, NiBS research focusing on response inhibition has mostly been conducted on younger adults. These extant studies have primarily focused on modulating the activity of distinct neural regions known to be critical for response inhibition, including the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA). However, given that changes in structural and functional connectivity have been associated with healthy aging, this review proposes that NiBS protocols aimed at modulating the functional connectivity between the rIFG and pre-SMA may be the most efficacious approach to investigate-and perhaps even alleviate-age-related deficits in inhibitory control.",
keywords = "Aging, Response inhibition, Neural oscillations, Functional connectivity, Phase synchronization, Transcranial alternating current stimulation (tACS), MILD COGNITIVE IMPAIRMENT, TRANSCRANIAL MAGNETIC STIMULATION, INFERIOR FRONTAL GYRUS, HUMAN MOTOR CORTEX, THETA-BURST STIMULATION, STOP-SIGNAL TASK, BASAL-GANGLIA, EXECUTIVE FUNCTIONS, ALZHEIMERS-DISEASE, CORTICOSPINAL EXCITABILITY",
author = "Jane Tan and Iyer, {Kartik K.} and Tang, {Alexander D.} and Asif Jamil and Martins, {Ralph N.} and Sohrabi, {Hamid R.} and Nitsche, {Michael A.} and Hinder, {Mark R.} and Hakuei Fujiyama",
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Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition : A narrative review. / Tan, Jane; Iyer, Kartik K.; Tang, Alexander D.; Jamil, Asif; Martins, Ralph N.; Sohrabi, Hamid R.; Nitsche, Michael A.; Hinder, Mark R.; Fujiyama, Hakuei.

In: NeuroImage, Vol. 185, 15.01.2019, p. 490-512.

Research output: Contribution to journalReview article

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T2 - A narrative review

AU - Tan, Jane

AU - Iyer, Kartik K.

AU - Tang, Alexander D.

AU - Jamil, Asif

AU - Martins, Ralph N.

AU - Sohrabi, Hamid R.

AU - Nitsche, Michael A.

AU - Hinder, Mark R.

AU - Fujiyama, Hakuei

PY - 2019/1/15

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AB - Response inhibition, the ability to withhold a dominant and prepotent response following a change in circumstance or sensory stimuli, declines with advancing age. While non-invasive brain stimulation (NiBS) has shown promise in alleviating some cognitive and motor functions in healthy older individuals, NiBS research focusing on response inhibition has mostly been conducted on younger adults. These extant studies have primarily focused on modulating the activity of distinct neural regions known to be critical for response inhibition, including the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA). However, given that changes in structural and functional connectivity have been associated with healthy aging, this review proposes that NiBS protocols aimed at modulating the functional connectivity between the rIFG and pre-SMA may be the most efficacious approach to investigate-and perhaps even alleviate-age-related deficits in inhibitory control.

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KW - BASAL-GANGLIA

KW - EXECUTIVE FUNCTIONS

KW - ALZHEIMERS-DISEASE

KW - CORTICOSPINAL EXCITABILITY

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