Modifying the phenyl group of PUGNAc: Reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases

Mitchell Hattie; N. Cekic; Aleksandra Debowski; D.J. Vocadlo; Keith Stubbs

doi:10.1039/c6ob00297h

Modifying the phenyl group of PUGNAc: Reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases

Mitchell Hattie, N. Cekic, Aleksandra Debowski, D.J. Vocadlo, Keith Stubbs

School of Molecular Sciences

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Abstract

© 2016 The Royal Society of Chemistry. The synthesis of analogues of the potent N-acetylhexosaminidase inhibitor, PUGNAc, are described. These compounds were assayed against a set of biologically important N-acetyl-d-glucosaminidases and were found to vary in both potency and selectivity.

Original language	English
Pages (from-to)	3193-3197
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	12
DOIs	https://doi.org/10.1039/c6ob00297h
Publication status	Published - 23 Feb 2016

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Hattie, M., Cekic, N., Debowski, A., Vocadlo, D. J., & Stubbs, K. (2016). Modifying the phenyl group of PUGNAc: Reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases. Organic and Biomolecular Chemistry, 14(12), 3193-3197. https://doi.org/10.1039/c6ob00297h

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AU - Stubbs, Keith

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N2 - © 2016 The Royal Society of Chemistry. The synthesis of analogues of the potent N-acetylhexosaminidase inhibitor, PUGNAc, are described. These compounds were assayed against a set of biologically important N-acetyl-d-glucosaminidases and were found to vary in both potency and selectivity.

AB - © 2016 The Royal Society of Chemistry. The synthesis of analogues of the potent N-acetylhexosaminidase inhibitor, PUGNAc, are described. These compounds were assayed against a set of biologically important N-acetyl-d-glucosaminidases and were found to vary in both potency and selectivity.

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DO - 10.1039/c6ob00297h

M3 - Article

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10.1039/c6ob00297h

Hattie et.al., 2016 Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidasesAccepted author manuscript, 272 KB

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Modifying the phenyl group of PUGNAc: Reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases

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