Modifying the phenyl group of PUGNAc: Reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases

Mitchell Hattie, N. Cekic, Aleksandra Debowski, D.J. Vocadlo, Keith Stubbs

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Abstract

© 2016 The Royal Society of Chemistry. The synthesis of analogues of the potent N-acetylhexosaminidase inhibitor, PUGNAc, are described. These compounds were assayed against a set of biologically important N-acetyl-d-glucosaminidases and were found to vary in both potency and selectivity.
Original languageEnglish
Pages (from-to)3193-3197
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number12
DOIs
Publication statusPublished - 23 Feb 2016

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