© 2016 The Royal Society of Chemistry. The synthesis of analogues of the potent N-acetylhexosaminidase inhibitor, PUGNAc, are described. These compounds were assayed against a set of biologically important N-acetyl-d-glucosaminidases and were found to vary in both potency and selectivity.
Hattie, M., Cekic, N., Debowski, A., Vocadlo, D. J., & Stubbs, K. (2016). Modifying the phenyl group of PUGNAc: Reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases. Organic and Biomolecular Chemistry, 14(12), 3193-3197. https://doi.org/10.1039/c6ob00297h