Modification of forearm resistance vessels by exercise training in young men

D.J. Green, N.T. Cable, C. Fox, J.M. Rankin, R.R. Taylor

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

The aim of this study was to determine whether a 4-wk handgrip training program would elicit changes in endothelium-dependent and endothelium-independent vasodilatation in resistance vessels of the human forearm. Minimum vascular resistance after a 10-min ischemic stimulus, an index of peak vasodilator capacity, was also determined. Forearm blood flow response to the endothelium-dependent vasodilator methacholine chloride did not change over the 4-wk intervention period either in the group undertaking training (n = 11) or in control subjects (n = 6). Similarly, the response to sodium nitroprusside was not influenced by the handgrip training program. Peak vasodilator capacity of the trained forearms significantly increased, whereas no change was evident in the untrained limbs. These results suggest that 4 wk of forearm exercise training enhances peak vasodilator capacity of the vasculature without influencing stimulated activity of the nitric oxide dilator system.

Original languageEnglish
Pages (from-to)1829-1833
Number of pages5
JournalJournal of Applied Physiology
Volume77
Issue number4
Publication statusPublished - Oct 1994

Fingerprint

Forearm
Vasodilator Agents
Exercise
Endothelium
Education
Endothelium-Dependent Relaxing Factors
Methacholine Chloride
Nitroprusside
Vasodilation
Vascular Resistance
Nitric Oxide
Extremities

Cite this

Green, D.J. ; Cable, N.T. ; Fox, C. ; Rankin, J.M. ; Taylor, R.R. / Modification of forearm resistance vessels by exercise training in young men. In: Journal of Applied Physiology. 1994 ; Vol. 77, No. 4. pp. 1829-1833.
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Modification of forearm resistance vessels by exercise training in young men. / Green, D.J.; Cable, N.T.; Fox, C.; Rankin, J.M.; Taylor, R.R.

In: Journal of Applied Physiology, Vol. 77, No. 4, 10.1994, p. 1829-1833.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Modification of forearm resistance vessels by exercise training in young men

AU - Green, D.J.

AU - Cable, N.T.

AU - Fox, C.

AU - Rankin, J.M.

AU - Taylor, R.R.

PY - 1994/10

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AB - The aim of this study was to determine whether a 4-wk handgrip training program would elicit changes in endothelium-dependent and endothelium-independent vasodilatation in resistance vessels of the human forearm. Minimum vascular resistance after a 10-min ischemic stimulus, an index of peak vasodilator capacity, was also determined. Forearm blood flow response to the endothelium-dependent vasodilator methacholine chloride did not change over the 4-wk intervention period either in the group undertaking training (n = 11) or in control subjects (n = 6). Similarly, the response to sodium nitroprusside was not influenced by the handgrip training program. Peak vasodilator capacity of the trained forearms significantly increased, whereas no change was evident in the untrained limbs. These results suggest that 4 wk of forearm exercise training enhances peak vasodilator capacity of the vasculature without influencing stimulated activity of the nitric oxide dilator system.

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KW - MINIMUM VASCULAR RESISTANCE

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KW - BLOOD-FLOW

KW - CHRONIC INCREASES

KW - RELAXING FACTOR

KW - NITRIC-OXIDE

KW - RELEASE

KW - VASODILATION

KW - RELAXATION

KW - Nedlands

KW - MUSCLE

M3 - Article

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JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

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