Dimethylcyanamide (N=CNMe(2)) has been coordinated to both hard and soft electrophiles ((NH3)(5)Co3+, (NH3)(5)Os3+, (dien)Pt2+) which activate (similar to x 10(6)) the nitrile toward attack by nucleophiles such as ammonia and hydroxide. Amination with liquid ammonia gave a rare coordinated guanidine (N,N-dimethylguanidine) ligand, which NMR spectra and X-ray crystal structures show to be charge neutral rather than anionic. [(NH3)(5)CoNH=C(NH2)NMe(2)](S2O6)(3/2). H2O, CoC3H26N8O10S3, were triclinic, space group , a = 11.565(2) Angstrom, b = 10.629(5) Angstrom, c = 8.026(1) Angstrom, alpha = 84.93(3)degrees, beta = 76.01(1)degrees, gamma = 73.82(3)degrees, V = 919.2(5) Angstrom(3), Z = 2, and R(F) (R(wF)) = 0.038 (0.047) for 3262 observed reflections (I > 3.0 sigma(I). Crystals of [(dien)PtNH=C(NH2)NMe(2)](CF3SO3)(2), PtC9H22N6O6 S2F6, are monoclinic, space group P2(1)/c, a = 13.857(4), b = 14.748(4) Angstrom, c = 22.092(4) Angstrom, beta = 105.38(2)degrees, V = 4353(2) Angstrom(3), Z = 8, and R(F) (R(wF)) = 0.034 (0.038) for 6778 reflections. Coordination geometries around the metals are octahedral and square planar, respectively, the guanidine skeletons being planar with bond angles and lengths characteristic of the metal-imino (rather than metal-amino) tautomer. The complexes are very stable in coordinating solvents (DMSO; water, pH 3-11) indicating high affinity of guanidine ligands for metal ions. Hydration of the dimethylcyanamide ligand is base-catalyzed, and first-order in [OH-] (0.05-0.5 M NaOH; k = k(s) + k(OH)[OH-], k(OH) = 2-5 M(-1) s(-1), 25 degrees C), in each case producing coordinated N,N-dimethylurea ([dienPtNHCONMe(2)](+), [(NH3)(5)CoNHCONMe(2)](2+), [(NH3)(5)OsNHCONMe(2)](2+)). Hydration rates are surprizingly similar despite differing radial extensions of the metal d-orbitals, a finding consistent with their comparable polarizing powers but contrary to expectation from other work. The relevance of metal activation of nitriles to biological systems is discussed.
Fairlie, D. P., Jackson, W. G., Skelton, B., Wen, H., White, A., Wickramasinghe, W. A., ... Taube, H. (1997). Models for Arginine-Metal Binding. Synthesis of Guanidine and Urea Ligands through Amination and Hydration of a Cyanamide Ligand Bound to Platinum(II), Osmium(III), and Cobalt(III). Inorganic Chemistry, 36(6), 1020-1028. https://doi.org/10.1021/ic961138e