Modelling of gas exchange in the lung during nitrous oxide anaesthesia

Ben Korman

doi:10.26182/fejs-kj24

Modelling of gas exchange in the lung during nitrous oxide anaesthesia

Ben Korman

Research output: Thesis › Doctoral Thesis

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Abstract

Since 2000, it has become clear that gas exchange in the lungs can be improved in the presence of mismatch between gas flow and blood flow. This contradicts a long-held belief that gas exchange can never be more efficient than when the two flows are perfectly matched throughout the lung. New modelling techniques were developed and a fundamental property of gas exchange in the lungs discovered which clarified how this is possible. It was shown that current measurements may underestimate the depth of anaesthesia and that many theoretical results require modification when the newly-defined property is taken into account.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Abarzhi, Snezhana, Supervisor Marshall, Barry, Supervisor Peyton, Philip, Supervisor, External person Schug, Stephan, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	15 Sept 2020
DOIs	https://doi.org/10.26182/fejs-kj24
Publication status	Unpublished - 2020

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THESIS - DOCTOR OF PHILOSOPHY - KORMAN, Bengt - 2020
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Cite this

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abstract = "Since 2000, it has become clear that gas exchange in the lungs can be improved in the presence of mismatch between gas flow and blood flow. This contradicts a long-held belief that gas exchange can never be more efficient than when the two flows are perfectly matched throughout the lung. New modelling techniques were developed and a fundamental property of gas exchange in the lungs discovered which clarified how this is possible. It was shown that current measurements may underestimate the depth of anaesthesia and that many theoretical results require modification when the newly-defined property is taken into account.",

keywords = "anaesthetic uptake, concentration effect, Mathematical modelling, second gas effect, ventilation-perfusion mismatch",

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AB - Since 2000, it has become clear that gas exchange in the lungs can be improved in the presence of mismatch between gas flow and blood flow. This contradicts a long-held belief that gas exchange can never be more efficient than when the two flows are perfectly matched throughout the lung. New modelling techniques were developed and a fundamental property of gas exchange in the lungs discovered which clarified how this is possible. It was shown that current measurements may underestimate the depth of anaesthesia and that many theoretical results require modification when the newly-defined property is taken into account.

KW - anaesthetic uptake

KW - concentration effect

KW - Mathematical modelling

KW - second gas effect

KW - ventilation-perfusion mismatch

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M3 - Doctoral Thesis

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Modelling of gas exchange in the lung during nitrous oxide anaesthesia

Abstract

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