Modelling multi-cellular networks

Rui Hou

Research output: ThesisDoctoral Thesis

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Abstract

Cells in multicellular organisms rely on thousands of different ligand-receptor pairs to coordinate the activities of multiple cell types throughout all stages of life. This thesis focuses on the development of three computational tools for analysing cell-to-cell communication networks using bulk and single-cell gene expression datasets. scMatch is able to automatically reveal the identity of each cell, NATMI helps construct the intercellular communication network among the identified cell types and HyperCommunity uses a novel mathematical model to mine the properties of the resulting communication network. Overall, this thesis provides a thorough cell-to-cell communication network analysis framework.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Forrest, Alistair, Supervisor
  • Small, Michael, Supervisor
Thesis sponsors
Award date10 May 2021
DOIs
Publication statusUnpublished - 2020

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