TY - JOUR
T1 - Modelled estimates of hospitalisations attributable to respiratory syncytial virus and influenza in Australia, 2009–2017
AU - Nazareno, Allen L.
AU - Muscatello, David J.
AU - Turner, Robin M.
AU - Wood, James G.
AU - Moore, Hannah C.
AU - Newall, Anthony T.
N1 - Funding Information:
We acknowledge a small amount of internal funding from the School of Population Health, University of New South Wales.
Funding Information:
The Australian Institute of Health and Welfare (AIHW) provided the hospitalisation data used in this study. Allen Nazareno was a recipient of the University International Postgraduate Award (UIPA) from the University of New South Wales. David Muscatello is supported by an NHMRC Investigator Grant (APP1194109). The contents of the published material are solely the responsibility of the Administering Institution, a Participating Institution or individual authors and do not reflect the views of the NHMRC.
Publisher Copyright:
© 2022 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.
PY - 2022/11
Y1 - 2022/11
N2 - Background: Respiratory syncytial virus (RSV) and influenza are important causes of disease in children and adults. In Australia, information on the burden of RSV in adults is particularly limited. Methods: We used time series analysis to estimate respiratory, acute respiratory infection, pneumonia and influenza, and bronchiolitis hospitalisations attributable to RSV and influenza in Australia during 2009 through 2017. RSV and influenza-coded hospitalisations in <5-year-olds were used as proxies for relative weekly viral activity. Results: From 2009 to 2017, the estimated all-age average annual rates of respiratory hospitalisations attributable to RSV and seasonal influenza (excluding 2009) were 54.8 (95% confidence interval [CI]: 20.1, 88.8) and 87.8 (95% CI: 74.5, 97.7) per 100,000, respectively. The highest estimated average annual RSV-attributable respiratory hospitalisation rate per 100,000 was 464.2 (95% CI: 285.9, 641.2) in <5-year-olds. For seasonal influenza, it was 521.6 (95% CI: 420.9, 600.0) in persons aged ≥75 years. In ≥75-year-olds, modelled estimates were approximately eight and two times the coded estimates for RSV and seasonal influenza, respectively. Conclusions: RSV and influenza are major causes of hospitalisation in young children and older adults in Australia, with morbidity underestimated by hospital diagnosis codes.
AB - Background: Respiratory syncytial virus (RSV) and influenza are important causes of disease in children and adults. In Australia, information on the burden of RSV in adults is particularly limited. Methods: We used time series analysis to estimate respiratory, acute respiratory infection, pneumonia and influenza, and bronchiolitis hospitalisations attributable to RSV and influenza in Australia during 2009 through 2017. RSV and influenza-coded hospitalisations in <5-year-olds were used as proxies for relative weekly viral activity. Results: From 2009 to 2017, the estimated all-age average annual rates of respiratory hospitalisations attributable to RSV and seasonal influenza (excluding 2009) were 54.8 (95% confidence interval [CI]: 20.1, 88.8) and 87.8 (95% CI: 74.5, 97.7) per 100,000, respectively. The highest estimated average annual RSV-attributable respiratory hospitalisation rate per 100,000 was 464.2 (95% CI: 285.9, 641.2) in <5-year-olds. For seasonal influenza, it was 521.6 (95% CI: 420.9, 600.0) in persons aged ≥75 years. In ≥75-year-olds, modelled estimates were approximately eight and two times the coded estimates for RSV and seasonal influenza, respectively. Conclusions: RSV and influenza are major causes of hospitalisation in young children and older adults in Australia, with morbidity underestimated by hospital diagnosis codes.
KW - burden
KW - epidemiology
KW - influenza hospitalisation
KW - regression modelling
KW - RSV hospitalisation
KW - time series analysis
UR - http://www.scopus.com/inward/record.url?scp=85133135751&partnerID=8YFLogxK
U2 - 10.1111/irv.13003
DO - 10.1111/irv.13003
M3 - Article
C2 - 35775106
AN - SCOPUS:85133135751
SN - 1750-2640
VL - 16
SP - 1082
EP - 1090
JO - Influenza and Other Respiratory Viruses
JF - Influenza and Other Respiratory Viruses
IS - 6
ER -