Abstract
Mitochondria are sub-cellular organelles responsible for generating the majority of cellular energy. These organelles contain
their own genetic material and protein synthesis machinery that produces the energy generation system. Changes in the
abundance or function of the mitochondrial protein synthesis machinery can lead to multi-systemic disorders. Elucidating
the molecular mechanisms of mitochondrial protein synthesis has provided invaluable insight into how genetic mutations in
mitochondrial proteins can cause debilitating and lethal diseases. This work has revealed how the severity of defects in protein
synthesis are tissue specific and can be influenced by environmental factors and stresses.
their own genetic material and protein synthesis machinery that produces the energy generation system. Changes in the
abundance or function of the mitochondrial protein synthesis machinery can lead to multi-systemic disorders. Elucidating
the molecular mechanisms of mitochondrial protein synthesis has provided invaluable insight into how genetic mutations in
mitochondrial proteins can cause debilitating and lethal diseases. This work has revealed how the severity of defects in protein
synthesis are tissue specific and can be influenced by environmental factors and stresses.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 25 Mar 2020 |
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| Publication status | Unpublished - 2020 |