Mitochondrial translation defects lead to different multi-systemic mitochondrial disorders

Nicola Ferreira

Research output: ThesisDoctoral Thesis

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Mitochondria are sub-cellular organelles responsible for generating the majority of cellular energy. These organelles contain
their own genetic material and protein synthesis machinery that produces the energy generation system. Changes in the
abundance or function of the mitochondrial protein synthesis machinery can lead to multi-systemic disorders. Elucidating
the molecular mechanisms of mitochondrial protein synthesis has provided invaluable insight into how genetic mutations in
mitochondrial proteins can cause debilitating and lethal diseases. This work has revealed how the severity of defects in protein
synthesis are tissue specific and can be influenced by environmental factors and stresses.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
  • Filipovska, Aleksandra, Supervisor
  • Richman, Tara, Supervisor
Thesis sponsors
Award date25 Mar 2020
Publication statusUnpublished - 2020


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